{"created":"2023-05-15T14:36:32.223616+00:00","id":47057,"links":{},"metadata":{"_buckets":{"deposit":"7b5452a2-2e7a-43d9-904d-afdf5973cecf"},"_deposit":{"created_by":1,"id":"47057","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"47057"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00047057","sets":["1"]},"author_link":["469876","469881","469883","469879","469877","469885","469880","469878","469882","469884"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-10","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"84","bibliographicPageStart":"76","bibliographicVolumeNumber":"95","bibliographic_titles":[{"bibliographic_title":"Applied Radiation and Isotopes"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"[18F]NS10743, a promising and highly competitive α7 nAChR radioligand has been synthesized so far by microwave irradiation using a manual single-mode device followed by a palladium-catalyzed reduction of remaining nitro-precursor for HPLC separation purposes. For further preclinical and clinical use, regulated production of [18F]NS10743 by fully automated radiosynthesis is a crucial requirement. Therefore, we chose a commercial synthesis module and developed the automated radiosynthesis of [18F]NS10743. Besides evaluation of several radiosynthesis procedures, we performed an extensive HPLC study for quantitative separation of [18F]NS10743 from the corresponding nitro precursor. After implementation of the optimized procedure on a TRACERlabTM FX F-N synthesis module, [18F]NS10743 was obtained in high radiochemical purity (≥99%) with an overall radiochemical yield of 32.2±7% (n=3). The specific activities at the end of the synthesis were 571±17 GBq/µmol (n=3).","subitem_description_type":"Abstract"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"25464181","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.apradiso.2014.09.016","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0969-8043","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Teodoro, Rodrigo"}],"nameIdentifiers":[{"nameIdentifier":"469876","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Wenzel, Barbara"}],"nameIdentifiers":[{"nameIdentifier":"469877","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Oh-Nishi, Arata"}],"nameIdentifiers":[{"nameIdentifier":"469878","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fischer, Steffen"}],"nameIdentifiers":[{"nameIdentifier":"469879","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Peters, Dan"}],"nameIdentifiers":[{"nameIdentifier":"469880","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suhara, Tetsuya"}],"nameIdentifiers":[{"nameIdentifier":"469881","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Deuther-Conrad, Winnie"}],"nameIdentifiers":[{"nameIdentifier":"469882","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Brust, Peter"}],"nameIdentifiers":[{"nameIdentifier":"469883","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大西 新","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"469884","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原 哲也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"469885","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"A high-yield automated radiosynthesis of the alpha-7nicotinic receptor radioligand[18F]NS10743","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A high-yield automated radiosynthesis of the alpha-7nicotinic receptor radioligand[18F]NS10743"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-03-25"},"publish_date":"2015-03-25","publish_status":"0","recid":"47057","relation_version_is_last":true,"title":["A high-yield automated radiosynthesis of the alpha-7nicotinic receptor radioligand[18F]NS10743"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:44:25.165724+00:00"}