@article{oai:repo.qst.go.jp:00047057,
 author = {Teodoro, Rodrigo and Wenzel, Barbara and Oh-Nishi, Arata and Fischer, Steffen and Peters, Dan and Suhara, Tetsuya and Deuther-Conrad, Winnie and Brust, Peter and 大西 新 and 須原 哲也},
 journal = {Applied Radiation and Isotopes},
 month = {Oct},
 note = {[18F]NS10743, a promising and highly competitive α7 nAChR radioligand has been synthesized so far by microwave irradiation using a manual single-mode device followed by a palladium-catalyzed reduction of remaining nitro-precursor for HPLC separation purposes. For further preclinical and clinical use, regulated production of [18F]NS10743 by fully automated radiosynthesis is a crucial requirement. Therefore, we chose a commercial synthesis module and developed the automated radiosynthesis of [18F]NS10743. Besides evaluation of several radiosynthesis procedures, we performed an extensive HPLC study for quantitative separation of [18F]NS10743 from the corresponding nitro precursor. After implementation of the optimized procedure on a TRACERlabTM FX F-N synthesis module, [18F]NS10743 was obtained in high radiochemical purity (≥99%) with an overall radiochemical yield of 32.2±7% (n=3). The specific activities at the end of the synthesis were 571±17 GBq/µmol (n=3).},
 pages = {76--84},
 title = {A high-yield automated radiosynthesis of the alpha-7nicotinic receptor radioligand[18F]NS10743},
 volume = {95},
 year = {2014}
}