@article{oai:repo.qst.go.jp:00046999,
 author = {Sekiguchi, Yuta and Takuwa, Hiroyuki and Kawaguchi, Hiroshi and Kikuchi, Takahiro and Okada, Eiji and Kanno, Iwao and Ito, Hiroshi and Tomita, Yutaka and Itoh, Yoshiaki and Suzuki, Norihiro and Sudo, Ryo and Tanishita, Kazuo and Masamoto, Kazuto and 関口 優太 and 田桑 弘之 and 川口 拓之 and 菊地 貴広 and 菅野 巖 and 伊藤 浩 and 冨田 裕 and 正本 和人},
 issue = {11},
 journal = {Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
 month = {Jul},
 note = {The pial and penetrating arteries have a crucial role in regulating cerebral blood flow (CBF) to meet neural demand in the cortex. Here, we examined the longitudinal effects of chronic hypoxia on the arterial diameter responses to single whisker stimulation in the awake mouse cortex, where activity-induced responses of CBF were gradually attenuated. The vasodilation responses to whisker stimulation under prehypoxia normal conditions were 8.1% and 12% relative to their baselines in the pial arteries and penetrating arterioles, respectively. After 3 weeks of hypoxia, however, these responses were significantly reduced to 5.5% and 4.1%, respectively. The CBF response, measured using laser-Doppler flowmetry (LDF), induced by the same whisker stimulation was also attenuated (14% to 2.6%). A close linear correlation was found for the responses between the penetrating arteriolar diameter and LDF, and their temporal dynamics. After 3 weeks of chronic hypoxia, the initiation of vasodilation in the penetrating arterioles was significantly extended, but the pial artery responses remained unchanged. These results show that vasodilation of the penetrating arterioles followed the pial artery responses, which are not explainable in terms of proximal integration signaling. The findings therefore indicate an additional mechanism for triggering pial artery dilation in the neurovascular coupling.Journal of Cerebral Blood Flow & Metabolism advance online publication, 30 July 2014; doi:10.1038/jcbfm.2014.140.},
 pages = {1761--1770},
 title = {Pial arteries respond earlier than penetrating arterioles to neural activation in the somatosensory cortex in awake mice exposed to chronic hypoxia: an additional mechanism to proximal integration signaling?},
 volume = {34},
 year = {2014}
}