@article{oai:repo.qst.go.jp:00046991,
 author = {Koto, Masashi and Hasegawa, Azusa and Takagi, Ryo and Ikawa, Hiroaki and Kamada, Tadashi and 小藤 昌志 and 長谷川 安都佐 and 高木 亮 and 伊川 裕明 and 鎌田 正},
 issue = {2},
 journal = {Jounal of Radiology & Radiation Therapy},
 month = {Sep},
 note = {Radiotherapy (RT) is a definitive treatment option for cancers of the head and
neck. Indeed, the most common pathology of head and neck lesions, Squamous Cell
Carcinoma (SCC), is radiosensitive. Recently, RT with chemotherapy has been shown to
improve the local control and survival rates among patients with head and neck SCC.
However, tumors arising in the head and neck region are of a variety of histological
types, including adenoid cystic carcinoma, mucosal malignant melanoma, and bone and
soft tissue sarcoma. Most of these tumors are resistant to RT, and therefore, RT is limited
to postoperative or palliative care for these tumors. Carbon ions offer a biological
advantage because, as compared with photons, carbon ions have higher linear energy
transfer components in the Bragg peak. Carbon ions also provide a higher degree of
physical selectivity because they have a finite range in tissue. Therefore, carbon ion
RT permits better dose conformity than can be obtained with photon RT. Consequently,
carbon ion RT can potentially control radio-resistant tumors while sparing normal
tissues. This review summarizes clinical studies of carbon ion radiotherapy for head　and neck cancers, especially non-SCCs.},
 title = {Carbon Ion Radiotherapy for Head and Neck Cancer},
 volume = {2},
 year = {2014}
}