{"created":"2023-05-15T14:36:29.067471+00:00","id":46984,"links":{},"metadata":{"_buckets":{"deposit":"cd3bf11e-3bfa-4b47-84ef-80d08a2d4d1f"},"_deposit":{"created_by":1,"id":"46984","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"46984"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00046984","sets":["1"]},"author_link":["468995","468993","468998","468992","468985","468987","468988","468986","468990","468994","468996","468984","468991","468989","468997"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"1032","bibliographicPageStart":"1023","bibliographicVolumeNumber":"57","bibliographic_titles":[{"bibliographic_title":"Journal of Medicinal Chemistry"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Multidrug resistance-associated protein 1\n(MRP1) is a drug efflux transporter that has been implicated\nin the pathology of several neurological diseases and is\nassociated with development of multidrug resistance. To\nenable measurement of MRP1 function in the living brain, a\nseries of 6-halopurines decorated with fluorinated side chains\nhave been synthesized and evaluated as putative pro-drug\ntracers. The tracers were designed to undergo conjugation\nwith glutathione within the brain and hence form the\ncorresponding MRP1 substrate tracers in situ. 6-Bromo-7-(2-\n[18F]fluoroethyl)purine showed good brain uptake and rapid\nmetabolic conversion. Dynamic PET imaging demonstrated a\nmarked difference in brain clearance rates between wild-type and mrp1 knockout mice, suggesting that the tracer can allow\nnoninvasive assessment of MRP1 activity in vivo.","subitem_description_type":"Abstract"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"24456310","subitem_relation_type_select":"PMID"}}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Galante, Eva"}],"nameIdentifiers":[{"nameIdentifier":"468984","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okamura, Toshimitsu"}],"nameIdentifiers":[{"nameIdentifier":"468985","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sander, Kerstin"}],"nameIdentifiers":[{"nameIdentifier":"468986","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kikuchi, Tatsuya"}],"nameIdentifiers":[{"nameIdentifier":"468987","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okada, Maki"}],"nameIdentifiers":[{"nameIdentifier":"468988","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Ming-Rong"}],"nameIdentifiers":[{"nameIdentifier":"468989","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Robson, Mathew"}],"nameIdentifiers":[{"nameIdentifier":"468990","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Badar, Adam"}],"nameIdentifiers":[{"nameIdentifier":"468991","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Lythgoe, Mark"}],"nameIdentifiers":[{"nameIdentifier":"468992","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Koepp, Matthias"}],"nameIdentifiers":[{"nameIdentifier":"468993","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Årstad, Erik"}],"nameIdentifiers":[{"nameIdentifier":"468994","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岡村 敏充","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"468995","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"菊池 達矢","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"468996","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岡田 真希","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"468997","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 明栄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"468998","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Development of Purine-Derived 18F‑Labeled Pro-drug Tracers for Imaging of MRP1 Activity with PET","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Development of Purine-Derived 18F‑Labeled Pro-drug Tracers for Imaging of MRP1 Activity with PET"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-12-16"},"publish_date":"2014-12-16","publish_status":"0","recid":"46984","relation_version_is_last":true,"title":["Development of Purine-Derived 18F‑Labeled Pro-drug Tracers for Imaging of MRP1 Activity with PET"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:45:17.414397+00:00"}