{"created":"2023-05-15T14:36:27.849884+00:00","id":46956,"links":{},"metadata":{"_buckets":{"deposit":"6acb44ae-b8ce-459c-a14b-41dfac93333e"},"_deposit":{"created_by":1,"id":"46956","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"46956"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00046956","sets":["1"]},"author_link":["468614","468613","468615"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"12","bibliographicPageStart":"e29141","bibliographicVolumeNumber":"6","bibliographic_titles":[{"bibliographic_title":"PLoS ONE (Online only:URL:http://www.plosone.org)"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Activation-induced cytidine deaminase (AID), produced by the Aicda gene, is essential for the immunoglobulin gene (Ig) alterations that form immune memory. Using a Cre-mediated genetic system, we unexpectedly found CD4+ T cells that had expressed Aicda (exAID cells) as well as B cells. ExAID cells increased with age, reaching up to 25% of the CD4+ and B220+ cell populations. ExAID B cells remained IgM+, suggesting that class-switched memory B cells do not accumulate in the spleen. In T cells, AID was expressed in a subset that produced IFN-γ and IL-10 but little IL-4 or IL-17, and showed no evidence of genetic mutation. Interestingly, the endogenous Aicda expression in T cells was enhanced in the absence of B cells, indicating that the process is independent from the germinal center reaction. These results suggest that in addition to its roles in B cells, AID may have previously unappreciated roles in T-cell function or tumorigenesis.","subitem_description_type":"Abstract"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"22216188","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1371/journal.pone.0029141","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1932-6203","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"中島, 菜花子"}],"nameIdentifiers":[{"nameIdentifier":"468613","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hongyan, et.al Qin"}],"nameIdentifiers":[{"nameIdentifier":"468614","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中島 菜花子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"468615","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Activation-induced cytidine deaminase expression in CD4+ T cells is associated with a unique IL-10-producing subset that increases with age.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Activation-induced cytidine deaminase expression in CD4+ T cells is associated with a unique IL-10-producing subset that increases with age."}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-11-19"},"publish_date":"2014-11-19","publish_status":"0","recid":"46956","relation_version_is_last":true,"title":["Activation-induced cytidine deaminase expression in CD4+ T cells is associated with a unique IL-10-producing subset that increases with age."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:45:37.620875+00:00"}