{"created":"2023-05-15T14:36:26.975044+00:00","id":46936,"links":{},"metadata":{"_buckets":{"deposit":"86cb726c-d8e6-4c90-8e1d-bfb53685bc62"},"_deposit":{"created_by":1,"id":"46936","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"46936"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00046936","sets":["1"]},"author_link":["468407","468405","468400","468401","468403","468406","468402","468404"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"564","bibliographicPageStart":"559","bibliographicVolumeNumber":"33","bibliographic_titles":[{"bibliographic_title":"International journal of molecular medicine"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The molecular chaperone heat shock protein 90 (Hsp90) is involved in the maturation and stabilization of a wide range of oncogenic client proteins for oncogenesis and malignant cell proliferation, which renders this protein a promising target in the development of cancer therapeutics. PU-H71 is a purine-scaffold Hsp90 inhibitor with less toxicity in normal cells than in cancer cells. In this study, we examined the in vitro radiosensitizing activity and molecular mechanisms of action of PU-H71 in human lung cancer cell lines. PU-H71 enhanced the sensitivity of the SQ-5 and A549 cancer cells to radiation. When the cancer cells were pre-treated with PU-H71, the repair of DNA double-strand breaks (DSBs) was markedly inhibited after irradiation compared with the cells that were not pre-treated with PU-H71, as evaluated by counting the foci of phosphorylated histone H2AX (γ-H2AX). We further demonstrated that post-irradiation, PU-H71 inhibited Rad51 foci formation, a critical protein for the homologous recombination pathway of DNA DSB repair. These data indicate that targeting Hsp90 with PU-H71 may be novel therapeutic strategy for radioresistant carcinomas.","subitem_description_type":"Abstract"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"24366006","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.3892/ijmm.2013.1594","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1107-3756","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Segawa, Tatsuya"}],"nameIdentifiers":[{"nameIdentifier":"468400","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fujii, Yoshihiro"}],"nameIdentifiers":[{"nameIdentifier":"468401","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tanaka, Aya"}],"nameIdentifiers":[{"nameIdentifier":"468402","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Bando, Shin-Ichi"}],"nameIdentifiers":[{"nameIdentifier":"468403","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okayasu, Ryuichi"}],"nameIdentifiers":[{"nameIdentifier":"468404","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ohnishi, Ken"}],"nameIdentifiers":[{"nameIdentifier":"468405","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kubota, Nobuo"}],"nameIdentifiers":[{"nameIdentifier":"468406","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岡安 隆一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"468407","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Radiosensitization of human lung cancer cells by the novel purine-scaffold Hsp90 inhibitor, PU-H71.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Radiosensitization of human lung cancer cells by the novel purine-scaffold Hsp90 inhibitor, PU-H71."}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-11-17"},"publish_date":"2014-11-17","publish_status":"0","recid":"46936","relation_version_is_last":true,"title":["Radiosensitization of human lung cancer cells by the novel purine-scaffold Hsp90 inhibitor, PU-H71."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:45:50.983987+00:00"}