{"created":"2023-05-15T14:36:26.931303+00:00","id":46935,"links":{},"metadata":{"_buckets":{"deposit":"d50d050d-ac76-41e7-bc8e-a3da4e2d9603"},"_deposit":{"created_by":1,"id":"46935","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"46935"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00046935","sets":["1"]},"author_link":["468392","468398","468395","468393","468391","468397","468399","468396","468394"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"109","bibliographicPageStart":"104","bibliographicVolumeNumber":"80","bibliographic_titles":[{"bibliographic_title":"Applied and environmental microbiology"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The roles of various core components, including α/β/γ-type small acid-soluble spore proteins (SASP), dipicolinic acid (DPA), core water content, and DNA repair by apurinic/apyrimidinic (AP) endonucleases or nonhomologous end joining (NHEJ), in Bacillus subtilis spore resistance to different types of ionizing radiation including X rays, protons, and high-energy charged iron ions have been studied. Spores deficient in DNA repair by NHEJ or AP endonucleases, the oxidative stress response, or protection by major α/β-type SASP, DPA, and decreased core water content were significantly more sensitive to ionizing radiation than wild-type spores, with highest sensitivity to high-energy-charged iron ions. DNA repair via NHEJ and AP endonucleases appears to be the most important mechanism for spore resistance to ionizing radiation, whereas oxygen radical detoxification via the MrgA-mediated oxidative stress response or KatX catalase activity plays only a very minor role. Synergistic radioprotective effects of α/β-type but not γ-type SASP were also identified, indicating that α/β-type SASP's binding to spore DNA is important in preventing DNA damage due to reactive oxygen species generated by ionizing radiation.","subitem_description_type":"Abstract"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"24123749","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1128/AEM.03136-13","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0099-2240","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Moeller, Ralf"}],"nameIdentifiers":[{"nameIdentifier":"468391","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Raguse, Marina"}],"nameIdentifiers":[{"nameIdentifier":"468392","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Reitz, Günther"}],"nameIdentifiers":[{"nameIdentifier":"468393","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岡安隆一"}],"nameIdentifiers":[{"nameIdentifier":"468394","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Li, Zuofeng"}],"nameIdentifiers":[{"nameIdentifier":"468395","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Klein, Stuart"}],"nameIdentifiers":[{"nameIdentifier":"468396","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Setlow, Peter"}],"nameIdentifiers":[{"nameIdentifier":"468397","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"L, Nicholson Wayne"}],"nameIdentifiers":[{"nameIdentifier":"468398","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岡安 隆一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"468399","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Resistance of Bacillus subtilis Spore DNA to Lethal Ionizing Radiation Damage Relies Primarily on Spore Core Components and DNA Repair, with Minor Effects of Oxygen Radical Detoxification.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Resistance of Bacillus subtilis Spore DNA to Lethal Ionizing Radiation Damage Relies Primarily on Spore Core Components and DNA Repair, with Minor Effects of Oxygen Radical Detoxification."}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-11-17"},"publish_date":"2014-11-17","publish_status":"0","recid":"46935","relation_version_is_last":true,"title":["Resistance of Bacillus subtilis Spore DNA to Lethal Ionizing Radiation Damage Relies Primarily on Spore Core Components and DNA Repair, with Minor Effects of Oxygen Radical Detoxification."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:45:51.673812+00:00"}