{"created":"2023-05-15T14:36:24.545689+00:00","id":46881,"links":{},"metadata":{"_buckets":{"deposit":"9f69b54e-78cd-441c-9f07-28b4108785fe"},"_deposit":{"created_by":1,"id":"46881","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"46881"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00046881","sets":["1"]},"author_link":["467784","467783","467780","467782","467781","467779","467785","467786"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"20","bibliographicPageEnd":"8897","bibliographicPageStart":"8891","bibliographicVolumeNumber":"33","bibliographic_titles":[{"bibliographic_title":"The Journal of neuroscience : the official journal of the Society for Neuroscience"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Ligands of the translocator protein (TSPO) elicit pleiotropic neuroprotective effects that represent emerging treatment strategies for several neurodegenerative conditions. To investigate the potential of TSPO as a therapeutic target for Alzheimer's disease (AD), the current study assessed the effects of the TSPO ligand Ro5-4864 on the development of neuropathology in 3xTgAD mice. The effects of the TSPO ligand on neurosteroidogenesis and AD-related neuropathology, including β-amyloid accumulation, gliosis, and behavioral impairment, were examined under both early intervention (7-month-old young-adult male mice with low pathology) and treatment (24-month-old, aged male mice with advanced neuropathology) conditions. Ro5-4864 treatment not only effectively attenuated development of neuropathology and behavioral impairment in young-adult mice but also reversed these indices in aged 3xTgAD mice. Reduced levels of soluble β-amyloid were also observed by the combination of TSPO ligands Ro5-4864 and PK11195 in nontransgenic mice. These findings suggest that TSPO is a promising target for the development of pleiotropic treatment strategies for the management of AD.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Society for Neuroscience"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"23678130","subitem_relation_type_select":"PMID"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0270-6474","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Barron Anna"}],"nameIdentifiers":[{"nameIdentifier":"467779","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"M, Garcia-Segura Luis"}],"nameIdentifiers":[{"nameIdentifier":"467780","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Caruso, Donatella"}],"nameIdentifiers":[{"nameIdentifier":"467781","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Jayaraman, Anusha"}],"nameIdentifiers":[{"nameIdentifier":"467782","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Lee, Joo-Won"}],"nameIdentifiers":[{"nameIdentifier":"467783","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"C, Melcangi Roberto"}],"nameIdentifiers":[{"nameIdentifier":"467784","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"J, Pike Christian"}],"nameIdentifiers":[{"nameIdentifier":"467785","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ｂａｒｒｏｎ Ａｎｎａ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"467786","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Ligand for translocator protein reverses pathology in a mouse model of Alzheimer's disease.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Ligand for translocator protein reverses pathology in a mouse model of Alzheimer's disease."}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-10-21"},"publish_date":"2014-10-21","publish_status":"0","recid":"46881","relation_version_is_last":true,"title":["Ligand for translocator protein reverses pathology in a mouse model of Alzheimer's disease."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:46:30.775253+00:00"}