@article{oai:repo.qst.go.jp:00046828,
 author = {Fujita, Mayumi and Imadome, Kaori and Endo, Satoshi and Shoji, Yoshimi and Yamada, Shigeru and Imai, Takashi and 藤田 真由美 and 今留 香織 and 遠藤 悟史 and 荘司 好美 and 山田 滋 and 今井 高志},
 issue = {17},
 journal = {FEBS letters},
 month = {Jul},
 note = {Previous studies have shown that serine proteases and Rho-associated kinase contribute to carbon ion radiation-enhanced invasion of the human pancreatic cancer cell line PANC-1. The results presented here show that nitric oxide synthase (NOS) also plays a critical role in this process. Irradiation of PANC-1 cells promoted invasion and production of nitric oxide (NO), which activated the PI3K-AKT signaling pathway, while independently activating RhoA. Inhibition of PI3K, Rho-associated kinase, and serine protease alone or in conjunction with NOS suppressed the radiation-enhanced invasion of PANC-1 cells, suggesting that they could serve as possible targets for the management of tumor metastasis.},
 pages = {3240--3250},
 title = {Nitric oxide increases the invasion of pancreatic cancer cells via activation of the PI3K-AKT and RhoA pathways after carbon ion irradiation.},
 volume = {588},
 year = {2014}
}