{"created":"2023-05-15T14:36:21.801368+00:00","id":46819,"links":{},"metadata":{"_buckets":{"deposit":"e1ed049a-a738-4bf5-b2ea-6c40e075ce72"},"_deposit":{"created_by":1,"id":"46819","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"46819"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00046819","sets":["1"]},"author_link":["467053","467054","467052","467051","467055","467056","467049","467050","467057"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"15","bibliographicPageEnd":"3625","bibliographicPageStart":"3622","bibliographicVolumeNumber":"24","bibliographic_titles":[{"bibliographic_title":"Bioorganic & Medicinal Chemistry Letters"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Retinoids are a class of chemical compounds which include both natural dietary vitamin A (retinol) metabolites and active synthetic analogs. Both experimental and clinical studies have revealed that retinoids regulate a wide variety of essential biological processes. In this study, we synthesized 11C-labeled\nall-trans-retinoic acid (ATRA), the most potent biologically active metabolite of retinol and used in the treatment of acute promyelocytic leukemia. The synthesis of 11C-labeled ATRA was accomplished by a combination of rapid Pd(0)-mediated C-[11C]methylation of the corresponding pinacol borate precursor\nprepared by 8 steps and hydrolysis. [11C]ATRA will prove useful as a PET imaging agent, particularly for elucidating the improved therapeutic activity of ATRA (natural retinoid) for acute promyelocytic leukemia by comparing with the corresponding PET probe [11C]Tamibarotene (artificial retinoid).\n  ","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"DOI:10.1016/j.bmcl.2014.05.04/","subitem_relation_type_select":"DOI"}}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Suzuki, Masaaki"}],"nameIdentifiers":[{"nameIdentifier":"467049","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takashima-Hirano, Misato"}],"nameIdentifiers":[{"nameIdentifier":"467050","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishii, Hideki"}],"nameIdentifiers":[{"nameIdentifier":"467051","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Watanabe, Chika"}],"nameIdentifiers":[{"nameIdentifier":"467052","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sumi, Kengo"}],"nameIdentifiers":[{"nameIdentifier":"467053","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Koyama, Hiroko"}],"nameIdentifiers":[{"nameIdentifier":"467054","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Doi, Hisashi"}],"nameIdentifiers":[{"nameIdentifier":"467055","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"石井 英樹","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"467056","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"土居 久志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"467057","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Synthesis of 11C-labeled retinoic acid, [11C]ATRA, via an alkenylboron precursor by Pd(0)-mediated rapid C-[11C]methylation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Synthesis of 11C-labeled retinoic acid, [11C]ATRA, via an alkenylboron precursor by Pd(0)-mediated rapid C-[11C]methylation"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-09-01"},"publish_date":"2014-09-01","publish_status":"0","recid":"46819","relation_version_is_last":true,"title":["Synthesis of 11C-labeled retinoic acid, [11C]ATRA, via an alkenylboron precursor by Pd(0)-mediated rapid C-[11C]methylation"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:47:13.901663+00:00"}