@article{oai:repo.qst.go.jp:00046798,
 author = {Ohta, Nobuo and Suzuki, Yusuke and Hasegawa, Azusa and Aoyagi, Masaru and kakehata, Seiji and 長谷川 安都佐},
 issue = {241856},
 journal = {Case Reports in Otolaryngology},
 month = {Jun},
 note = {Objective. To evaluate the treatment outcome and prognostic factors in patients with sinonasal malignant tumors invading skull base. Study Design and Setting. A retrospective clinical study at the Yamagata University School ofMedicine. Subjects andMethods.
Three patients with sinonasal malignant tumors invading skull base were presented in present study. All patients were treated with carbon ion beam radiotherapy. The prescribed dose to the center of the clinical target volume was 64.0GyE/16 fractions over 4 weeks at 4.0GyE/fraction per day. Results. All patients completed carbon ion beam radiotherapy without an interval. The mean
observation period was 39.6 months (range: 11–54 months). There were no local or regional recurrences in all cases; however, one patient had a metastasis in distant organs. Regarding the complications, visual loss was observed in one eye of one patient whose optic nerve was entirely involved by the tumor and field of carbon ion beam radiotherapy. Radiation induced brain injury was observed in two patients; however, these patients do not complain about neurological abnormality and had no treatment for radiation induced brain necrosis. Conclusions. Carbon ion beam radiotherapy for sinonasal malignant tumors invading the skull base showed therapeutic effectiveness.},
 title = {Carbon Ion Beam Radiotherapy for Sinonasal Malignant Tumors Invading Skull Base},
 volume = {2014},
 year = {2014}
}