@article{oai:repo.qst.go.jp:00046764,
 author = {Mizoe, Junetsu and Hasegawa, Azusa and Jingu, Keiichi and Takagi, Ryo and Bessho, Hiroki and Morikawa, Takamichi and Tonogi, Morio and Tsuji, Hiroshi and Kamada, Tadashi and Tsujii, Hirohiko and Okamoto, Yoshitaka and 溝江 純悦 and 長谷川 安都佐 and 神宮 啓一 and 高木 亮 and 別所 央城 and 森川 貴迪 and 外木 守雄 and 辻 比呂志 and 鎌田 正 and 辻井 博彦 and 岡本 美孝},
 issue = {1},
 journal = {Radiotherapy and Oncology},
 month = {Feb},
 note = {Purpose:To evaluate the efficacy of carbon ion radiotherapy for head-and-neck cancer in a phase II clin-ical trial.
Materials and methods:Between April 1997 and February 2006, 236 patients with locally advanced, his-tologically proven, and new or recurrent cancer of the head and neck were treated with carbon ions. The treatment dose was 64.0 GyE/16 fractions/4 weeks(or 57.6 GyE/16 fractions/4 weeks when the wide-range skin was included in the target volume).
Results: There were grade 3 acute skin reactions in 6% and grade 3 acute mucosal reactions in 10% with no acute reactions worse than grade 3, and grade 2 late skin reactions in 3% and grade 2 late mucosal reac-tions in 2% with no late reactions worse than grade 2.The 5-year local control rate, by histological type, was 75% for the 85 patients with malignant melanoma, 73% for the 69 with adenoid cystic carcinoma, 73% for the 27 with adenocarcinoma, 61% for the 13 with papillary adenocarcinoma, 61% for the 12 with squa-mous cell carcinoma and 24% for the 14 with sarcomas. The 5-year over-all survival rate was 68% for ade- noid cystic carcinoma, 56% for adenocarcinoma and 35% for malignant melanoma.
Conclusions: Carbon ion radiotherapy for head and neck cancer showed the therapeutic effectivaness for malignant melanoma and adenoid cyatic carcinama without severe morbidity of the normal tissues.},
 pages = {32--37},
 title = {Results of carbon ion radiotherapy for head and neck cacer},
 volume = {103},
 year = {2012}
}