{"created":"2023-05-15T14:36:19.259909+00:00","id":46761,"links":{},"metadata":{"_buckets":{"deposit":"a6cf8eea-7029-4553-928a-538e4b04831d"},"_deposit":{"created_by":1,"id":"46761","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"46761"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00046761","sets":["1"]},"author_link":["466354","466356","466349","466350","466348","466353","466345","466351","466357","466352","466359","466347","466346","466358","466360","466355"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"1531","bibliographicPageStart":"1524","bibliographicVolumeNumber":"78","bibliographic_titles":[{"bibliographic_title":"International Journal of Radiation Oncology Biology Physics"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Purpose: Our previous report indicated that carbon ion beam irradiation upregulated\nimmunogenic, underlining the potential clinical application of radioimmunotherapy. The antimetastatic efficacy of a local combination therapy of carbon-ion radiotherapy and immunotherapy was examined using in vivo murine model.\nMethods and Materials: Tumors of the mouse squamous cell carcinoma (NR-S1) cells inoculated in the leg of C3H/HeMsNrs mice were locally irradiated with a single 6 Gy dosage of carbon ions (290 MeV/nucleon, 6 cm spread-out Bragg peak). Thirty-six hours after irradiation, alpha-galactosylceramide (alpha-GalCer)-pulsed dendritic cells (DCs) were injected into the leg tumor. The effects on distant lung metastases were investigated using pathological observations and immunohistochemistry.\nResults: The mice in the control group, which were not irradiated and not injected with alpha-GalCerpulsed DCs, had 168 +/- 53.8 metastatic nodules in their lungs at 2 weeks. The lung metastases were significantly decreased in the mouse which received the combination therapy, and the mean number of lung metastatic nodules was 2.6 +/- 1.9 (P = 0.009). In addition, the size of each lung metastasis was significantly decreased in compared to the control group (P = 0.009). Immunohistochemistry showed that ICAM-1, which activates DCs, was highly expressed on the local tumors of the carbon ionirradiated group. The expression of S100A8 in lung tissue, a marker of the lung pre-metastatic phase, was decreased in the combination therapy group.\nConclusion: The combination of carbon ion radiotherapy with the injection of alpha-GalCer-pulsed DCs into the primary tumors significantly decreased the number of lung metastases.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0360-3016","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ohkubo, Yu"}],"nameIdentifiers":[{"nameIdentifier":"466345","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Iwakawa, Mayumi"}],"nameIdentifiers":[{"nameIdentifier":"466346","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Seino, Ken-ichiro"}],"nameIdentifiers":[{"nameIdentifier":"466347","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakawatari, Miyako"}],"nameIdentifiers":[{"nameIdentifier":"466348","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Wada, Haruka"}],"nameIdentifiers":[{"nameIdentifier":"466349","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kamijuku, Hajime"}],"nameIdentifiers":[{"nameIdentifier":"466350","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakamura, Etsuko"}],"nameIdentifiers":[{"nameIdentifier":"466351","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakano, Takashi"}],"nameIdentifiers":[{"nameIdentifier":"466352","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Imai, Takashi"}],"nameIdentifiers":[{"nameIdentifier":"466353","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大久保 悠","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"466354","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岩川 眞由美","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"466355","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"清野 研一郎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"466356","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中渡 美也子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"466357","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中村 悦子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"466358","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中野 隆史","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"466359","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"今井 高志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"466360","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Combining Carbon ion Radiotherapy and Local Injection of Alpha-galactosylceramide-pulsed Dendritic Cells Inhibits Lung Metastases in an in vivo Murine Model","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Combining Carbon ion Radiotherapy and Local Injection of Alpha-galactosylceramide-pulsed Dendritic Cells Inhibits Lung Metastases in an in vivo Murine Model"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-05-22"},"publish_date":"2014-05-22","publish_status":"0","recid":"46761","relation_version_is_last":true,"title":["Combining Carbon ion Radiotherapy and Local Injection of Alpha-galactosylceramide-pulsed Dendritic Cells Inhibits Lung Metastases in an in vivo Murine Model"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:47:54.716718+00:00"}