{"created":"2023-05-15T14:36:18.609001+00:00","id":46746,"links":{},"metadata":{"_buckets":{"deposit":"8e1228fb-8b30-4a01-9bc6-4cd3fec470d0"},"_deposit":{"created_by":1,"id":"46746","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"46746"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00046746","sets":["1"]},"author_link":["466179","466184","466189","466188","466183","466178","466181","466175","466182","466197","466186","466192","466172","466177","466187","466190","466185","466191","466194","466180","466170","466196","466171","466174","466193","466176","466173","466198","466195"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"23","bibliographicPageStart":"17","bibliographicVolumeNumber":"41","bibliographic_titles":[{"bibliographic_title":"Nuclear Medicine and Biology"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Introduction: [11C]ABP688 is a promising positron emission tomography (PET) ligand for imaging of\nmetabotropic glutamate receptor subtype 5 (mGlu5 receptor). Of the two geometric isomers of ABP688, (E)-\nABP688 has a greater affinity towards mGlu5 receptors than (Z)-ABP688. Therefore, a high ratio of E-isomer is\nrequired when using [11C]ABP688 as a PET probe for imaging and quantification of mGlu5 receptors. The aim\nof this study was to evaluate the effect (Z)-[11C]ABP688 on the synthesis of [11C]ABP688 to be used for binding\n(E)-[11C]ABP688 in the brain.\nMethods: We synthesized and separated (E)- and (Z)-[11C]ABP688 by purification using an improved\npreparative high-performance liquid chromatography (HPLC) method equipped with a COSMOSIL Cholester\ncolumn. We performed an in vitro binding assay in rat brain homogenates and PET studies of the rat brains\nusing (E)- and (Z)-[11C]ABP688.\nResults: (E)- and (Z)-[11C]ABP688 were successfully obtained with suitable radioactivity for application. In the\nin vitro assay, the Kd value of (E)-[11C]ABP688 (5.7 nmol/L) was higher than that of (Z)-[11C]ABP688 (140\nnmol/L). In the PET study of the rat brain, high radioactivity after injection of (E)-[11C]ABP688 was observed in\nregions rich in mGlu5 receptors such as the striatum and hippocampus. In contrast, after injection of (Z)-[11C]\nABP688, radioactivity did not accumulate in the brain. Furthermore, BPND in the striatum and hippocampus\nwas highly correlated (R2=0.99) with the percentage of (E)-[11C]ABP688 of the total radioactivity of (E)- and\n(Z)-[11C]ABP688 in the injection.\nConclusion: We demonstrated that including (Z)-[11C]ABP688 in the [11C]ABP688 injection can decrease BPND\nin regions rich in mGlu5 receptors. Routine production of (E)-[11C]ABP688 will be helpful for imaging and\nquantification of mGlu5 receptors in clinical studies.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"ELSEVIER"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"doi.org/10.1016/j.nucmedbio.2013.09.008","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0969-8051","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kawamura, Kazunori"}],"nameIdentifiers":[{"nameIdentifier":"466170","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamasaki, Tomoteru"}],"nameIdentifiers":[{"nameIdentifier":"466171","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kumata, Katsushi"}],"nameIdentifiers":[{"nameIdentifier":"466172","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Furutsuka, Kenji"}],"nameIdentifiers":[{"nameIdentifier":"466173","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takei, Makoto"}],"nameIdentifiers":[{"nameIdentifier":"466174","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Wakizaka, Hidekatsu"}],"nameIdentifiers":[{"nameIdentifier":"466175","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fujinaga, Masayuki"}],"nameIdentifiers":[{"nameIdentifier":"466176","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kaori, Kariya"}],"nameIdentifiers":[{"nameIdentifier":"466177","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yui, Joji"}],"nameIdentifiers":[{"nameIdentifier":"466178","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hatori, Akiko"}],"nameIdentifiers":[{"nameIdentifier":"466179","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Xie, Lin"}],"nameIdentifiers":[{"nameIdentifier":"466180","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shimoda, Yoko"}],"nameIdentifiers":[{"nameIdentifier":"466181","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hashimoto, Hiroki"}],"nameIdentifiers":[{"nameIdentifier":"466182","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hayashi, Kazutaka"}],"nameIdentifiers":[{"nameIdentifier":"466183","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Ming-Rong"}],"nameIdentifiers":[{"nameIdentifier":"466184","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"河村 和紀","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"466185","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山崎 友照","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"466186","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"熊田 勝志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"466187","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古塚 賢士","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"466188","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"武井 誠","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"466189","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"脇坂 秀克","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"466190","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤永 雅之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"466191","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"由井 譲二","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"466192","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"羽鳥 晶子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"466193","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"謝 琳","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"466194","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"下田 陽子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"466195","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"橋本 裕輝","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"466196","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"林 和孝","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"466197","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 明栄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"466198","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Binding potential of (E)-[11C]ABP688 to metabotropic glutamate receptor subtype 5 is decreased by the inclusion of its 11C-labelled Z-isomer","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Binding potential of (E)-[11C]ABP688 to metabotropic glutamate receptor subtype 5 is decreased by the inclusion of its 11C-labelled Z-isomer"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-03-18"},"publish_date":"2014-03-18","publish_status":"0","recid":"46746","relation_version_is_last":true,"title":["Binding potential of (E)-[11C]ABP688 to metabotropic glutamate receptor subtype 5 is decreased by the inclusion of its 11C-labelled Z-isomer"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:48:07.056955+00:00"}