{"created":"2023-05-15T14:36:18.521595+00:00","id":46744,"links":{},"metadata":{"_buckets":{"deposit":"105e7f2d-8f7f-42d3-bf10-20fe7ca56a31"},"_deposit":{"created_by":1,"id":"46744","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"46744"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00046744","sets":["1"]},"author_link":["466157","466152","466150","466148","466153","466154","466151","466155","466156","466149"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-07","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"13","bibliographicPageEnd":"678","bibliographicPageStart":"672","bibliographicVolumeNumber":"56","bibliographic_titles":[{"bibliographic_title":"Journal of Labelled Compounds & Radiopharmaceuticals"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The N- or O-methylation reactions of compounds bearing amide, aniline, or phenol moieties using iodo[11C]methane (1) with\nthe aid of a base are frequently applied to the preparation of 11C-labeled radiopharmaceuticals. Although sodium hydride\nand alkaline metal hydroxides are commonly employed as bases in these reactions, their poor solubility properties in\norganic solvents and hydrolytic activities have sometimes limited their application and made the associated 11C-methylation\nreactions difficult. In contrast to these bases, tetrabutylammonium fluoride (TBAF) is moderately basic, highly soluble in\norganic solvents, and weakly nucleophilic. Although it was envisaged that TBAF could be used as the preferred base for\n11C-methylation reactions using 1, studies concerning the use of TBAF to promote 11C-methylation reactions are scarce.\nHerein, we have evaluated the efficiency of the 11C-methylation reactions of 13 model compounds using TBAF and 1. In most\ncases, the N-11C-methylations were efficiently promoted by TBAF in dimethyl sulfoxide at ambient temperature, whereas the\nO-11C-methylations required heating in some cases. Comparison studies revealed that the efficiencies of the 11C-methylation\nreactions with TBAF were comparable or sometimes greater than those conducted with sodium hydride. Based on these\nresults, TBAF should be considered as the preferred base for 11C-methylation reactions using 1.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"wileyonlinelibrary"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"doi: 10.1002/jlcr.3092","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0362-4803","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kikuchi, Tatsuya"}],"nameIdentifiers":[{"nameIdentifier":"466148","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Minegishi, Katsuyuki"}],"nameIdentifiers":[{"nameIdentifier":"466149","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hashimoto, Hiroki"}],"nameIdentifiers":[{"nameIdentifier":"466150","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Ming-Rong"}],"nameIdentifiers":[{"nameIdentifier":"466151","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kato, Koichi"}],"nameIdentifiers":[{"nameIdentifier":"466152","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"菊池 達矢","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"466153","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"峯岸 克行","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"466154","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"橋本 裕輝","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"466155","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 明栄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"466156","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"加藤 孝一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"466157","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"The use of tetrabutylammonium fluoride to promote N- and O-11C-methylation reactions with iodo[11C]methane in dimethyl sulfoxide","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The use of tetrabutylammonium fluoride to promote N- and O-11C-methylation reactions with iodo[11C]methane in dimethyl sulfoxide"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-03-18"},"publish_date":"2014-03-18","publish_status":"0","recid":"46744","relation_version_is_last":true,"title":["The use of tetrabutylammonium fluoride to promote N- and O-11C-methylation reactions with iodo[11C]methane in dimethyl sulfoxide"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:48:08.513304+00:00"}