{"created":"2023-05-15T14:36:18.347506+00:00","id":46740,"links":{},"metadata":{"_buckets":{"deposit":"baa7aec4-0602-4596-984d-0540e0a28856"},"_deposit":{"created_by":1,"id":"46740","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"46740"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00046740","sets":["1"]},"author_link":["466097","466106","466103","466096","466099","466104","466098","466107","466101","466100","466102","466105"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"1064","bibliographicPageStart":"1057","bibliographicVolumeNumber":"54","bibliographic_titles":[{"bibliographic_title":"Journal of Radiation Research"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Accidental exposure of abdomen with high-dose radiation leads severe consequences\ninitiated by disruption of mucosa in small intestine. The practical choice of the clinical treatment\nis limited, even though various methods to cure the damage have been investigated particularly in\nthe field of regenerative therapy. To publish treatment methods that can be used for therapy\nreadily, we examined several current pharmaceutical drugs, whose safety estimations were\ncompleted, in mice underwent severe mucosal damage by radiation. Assuming as post-accidental\ntreatment, drugs were injected to mice 24 h after exposure at 15.7 Gy of x-ray. Effects of drugs on\ndamaged mucosa of small intestine were evaluated by early regeneration indexes, expression of\nc-myb mRNA and proliferation of epithelial cells as microcolony (MC) at Days 4 and 5 after\nirradiation. Finally, the effects of drugs on survival rate of mice with abdominal x-irradiation at\n15.7 Gy were examined. Enhancement of the mucosal regeneration at Day 4 (c-myb: P<0.01, MC:\nP<0.05) and improvement of the survival rate (P<0.05) were observed when clinical dose of\ngonadotropin, a stimulator of androgen, was injected. Similarly clinical dose of thiamazole that\nprevents secretion of thyroid hormone stimulated mucosal growth at Day 5 (c-myb: P<0.01, MC:\nP<0.05) and improved the survival rate (P<0.05). In the cases of nonclinical drugs, histamine and\nhigh dose of growth hormone antagonist, octreotide, showed significant life-saving effects (P<0.01and P<0.05, respectively). These results can be referred to construct therapeutic program and be\nutilized for basic studies to control regeneration of damaged mucosa.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"OXFORD UNIVERSITY PRESS"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0449-3060","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"石原, 弘"}],"nameIdentifiers":[{"nameIdentifier":"466096","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田中, 泉"}],"nameIdentifiers":[{"nameIdentifier":"466097","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"薬丸, 晴子"}],"nameIdentifiers":[{"nameIdentifier":"466098","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田中, 美香"}],"nameIdentifiers":[{"nameIdentifier":"466099","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"横地, 和子"}],"nameIdentifiers":[{"nameIdentifier":"466100","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"明石, 真言"}],"nameIdentifiers":[{"nameIdentifier":"466101","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"石原 弘","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"466102","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田中 泉","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"466103","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"薬丸 晴子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"466104","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田中 美香","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"466105","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"横地 和子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"466106","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"明石 真言","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"466107","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Pharmaceutical Drugs Supporting Regeneration of Small Intestinal Mucosa Severely Damaged by Ionizing Radiation in Mouse.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Pharmaceutical Drugs Supporting Regeneration of Small Intestinal Mucosa Severely Damaged by Ionizing Radiation in Mouse."}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-03-06"},"publish_date":"2014-03-06","publish_status":"0","recid":"46740","relation_version_is_last":true,"title":["Pharmaceutical Drugs Supporting Regeneration of Small Intestinal Mucosa Severely Damaged by Ionizing Radiation in Mouse."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:48:11.507075+00:00"}