@article{oai:repo.qst.go.jp:00046740,
 author = {石原, 弘 and 田中, 泉 and 薬丸, 晴子 and 田中, 美香 and 横地, 和子 and 明石, 真言 and 石原 弘 and 田中 泉 and 薬丸 晴子 and 田中 美香 and 横地 和子 and 明石 真言},
 issue = {6},
 journal = {Journal of Radiation Research},
 month = {Nov},
 note = {Accidental exposure of abdomen with high-dose radiation leads severe consequences
initiated by disruption of mucosa in small intestine. The practical choice of the clinical treatment
is limited, even though various methods to cure the damage have been investigated particularly in
the field of regenerative therapy. To publish treatment methods that can be used for therapy
readily, we examined several current pharmaceutical drugs, whose safety estimations were
completed, in mice underwent severe mucosal damage by radiation. Assuming as post-accidental
treatment, drugs were injected to mice 24 h after exposure at 15.7 Gy of x-ray. Effects of drugs on
damaged mucosa of small intestine were evaluated by early regeneration indexes, expression of
c-myb mRNA and proliferation of epithelial cells as microcolony (MC) at Days 4 and 5 after
irradiation. Finally, the effects of drugs on survival rate of mice with abdominal x-irradiation at
15.7 Gy were examined. Enhancement of the mucosal regeneration at Day 4 (c-myb: P<0.01, MC:
P<0.05) and improvement of the survival rate (P<0.05) were observed when clinical dose of
gonadotropin, a stimulator of androgen, was injected. Similarly clinical dose of thiamazole that
prevents secretion of thyroid hormone stimulated mucosal growth at Day 5 (c-myb: P<0.01, MC:
P<0.05) and improved the survival rate (P<0.05). In the cases of nonclinical drugs, histamine and
high dose of growth hormone antagonist, octreotide, showed significant life-saving effects (P<0.01and P<0.05, respectively). These results can be referred to construct therapeutic program and be
utilized for basic studies to control regeneration of damaged mucosa.},
 pages = {1057--1064},
 title = {Pharmaceutical Drugs Supporting Regeneration of Small Intestinal Mucosa Severely Damaged by Ionizing Radiation in Mouse.},
 volume = {54},
 year = {2013}
}