@article{oai:repo.qst.go.jp:00046720,
 author = {Suzuki, Chie and Kato, Koichi and Tsuji, Atsushi and Kikuchi, Tatsuya and Zhang, Ming-Rong and Arano, Yasushi and Saga, Tsuneo and 鈴木 千恵 and 加藤 孝一 and 辻 厚至 and 菊池 達矢 and 張 明栄 and 荒野 泰 and 佐賀 恒夫},
 issue = {16},
 journal = {Bioorganic & Medicinal Chemistry Letters},
 month = {Jun},
 note = {Protoporphyrin IX (PpIX) accumulation induced by exogenous 5-aminolevulinic acid (ALA) in tumors
affects the therapeutic efficacy of ALA-based photodynamic and sonodynamic therapies. To develop a
new imaging probe to estimate the ALA-induced PpIX accumulation, 11C-labeled ALA analog (4), an
ALA-dehydratase inhibitor, was radiosynthesized via 11C-methylation of a Schiff-base-activated precursor
in the presence of tetrabutylammonium fluoride, followed by the hydrolysis of ester and imine
groups. The cellular uptake of 4 linearly increased with time and was inhibited by ALA and other transporter
competitors. Monitoring analog 4 with positron emission tomography might be useful to estimate
the ALA-induced PpIX accumulation in tumors.},
 pages = {4567--4570},
 title = {Synthesis and in vitro cellular uptake of 11C-labeled 5-aminolevulinic acid derivative to estimate the induced cellular accumulation of protoporphyrin IX.},
 volume = {23},
 year = {2013}
}