{"created":"2023-05-15T14:36:15.559528+00:00","id":46676,"links":{},"metadata":{"_buckets":{"deposit":"1280c499-f0d6-47b0-9cff-33a6c7c0b0d6"},"_deposit":{"created_by":1,"id":"46676","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"46676"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00046676","sets":["1"]},"author_link":["465389","465377","465385","465382","465384","465387","465379","465380","465383","465378","465388","465381","465386"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageStart":"76","bibliographicVolumeNumber":"3","bibliographic_titles":[{"bibliographic_title":"EJNMMI research"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Recently, we reported an information density theory and an analysis of three-parameter plus shorter scan than conventional method (3P+) for the amyloid-binding ligand [11C]Pittsburgh compound B (PIB) as an\nexample of a non-highly reversible positron emission tomography (PET) ligand. This article describes an extension of 3P + analysis to noninvasive ‘3P++’ analysis (3P + plus use of a reference tissue for input function).\nMethods: In 3P++ analysis for [11C]PIB, the cerebellum was used as a reference tissue (negligible specific binding). Fifteen healthy subjects (NC) and fifteen Alzheimer's disease (AD) patients participated. The k3 (index of receptor\ndensity) values were estimated with 40-min PET data and three-parameter reference tissue model and were compared with that in 40-min 3P + analysis as well as standard 90-min four-parameter (4P) analysis with arterial input function. Simulation studies were performed to explain k3 biases observed in 3P++ analysis.\nResults: Good model fits of 40-min PET data were observed in both reference and target regions-of-interest (ROIs). High linear intra-subject (inter-15 ROI) correlations of k3 between 3P++ (Y-axis) and 3P + (X-axis) analyses were\nshown in one NC (r2 = 0.972 and slope = 0.845) and in one AD (r2 = 0.982, slope = 0.655), whereas inter-subject k3 correlations in a target region (left lateral temporal cortex) from 30 subjects (15 NC + 15 AD) were somewhat lower\n(r2 = 0.739 and slope = 0.461). Similar results were shown between 3P++ and 4P analyses: r2 = 0.953 for intra-subject k3 in NC, r2 = 0.907 for that in AD and r2 = 0.711 for inter-30 subject k3. Simulation studies showed that such lower\ninter-subject k3 correlations and significant negative k3 biases were not due to unstableness of 3P++ analysis but rather to inter-subject variation of both k2 (index of brain-to-blood transport) and k3 (not completely negligible) in\nthe reference region.\nConclusions: In [11C]PIB, the applicability of 3P++ analysis may be restricted to intra-subject comparison such as follow-up studies. The 3P++ method itself is thought to be robust and may be more applicable to other non-highly reversible PET ligands with ideal reference tissue.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"24238306","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1186/2191-219X-3-76","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://www.ejnmmires.com/content/3/1/76"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.ejnmmires.com/content/3/1/76","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2191-219X","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Sato, Koichi"}],"nameIdentifiers":[{"nameIdentifier":"465377","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fukushi, Kiyoshi"}],"nameIdentifiers":[{"nameIdentifier":"465378","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shinotoh, Hitoshi"}],"nameIdentifiers":[{"nameIdentifier":"465379","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shimada, Hitoshi"}],"nameIdentifiers":[{"nameIdentifier":"465380","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hirano, Shigeki"}],"nameIdentifiers":[{"nameIdentifier":"465381","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tanaka, Noriko"}],"nameIdentifiers":[{"nameIdentifier":"465382","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suhara, Tetsuya"}],"nameIdentifiers":[{"nameIdentifier":"465383","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Irie, Toshiaki"}],"nameIdentifiers":[{"nameIdentifier":"465384","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ito, Hiroshi"}],"nameIdentifiers":[{"nameIdentifier":"465385","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田 斉","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"465386","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"平野 成樹","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"465387","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原 哲也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"465388","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤 浩","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"465389","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Noninvasive k3 estimation method for slow dissociation PET ligands: application to [11C]Pittsburgh compound B.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Noninvasive k3 estimation method for slow dissociation PET ligands: application to [11C]Pittsburgh compound B."}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-12-12"},"publish_date":"2013-12-12","publish_status":"0","recid":"46676","relation_version_is_last":true,"title":["Noninvasive k3 estimation method for slow dissociation PET ligands: application to [11C]Pittsburgh compound B."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:48:56.194726+00:00"}