{"created":"2023-05-15T14:36:14.879576+00:00","id":46661,"links":{},"metadata":{"_buckets":{"deposit":"023a1834-ff9c-46f4-950b-3f537c9ce0fe"},"_deposit":{"created_by":1,"id":"46661","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"46661"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00046661","sets":["1"]},"author_link":["465168","465166","465170","465171","465169","465167","465165"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"207","bibliographicPageStart":"200","bibliographicVolumeNumber":"179","bibliographic_titles":[{"bibliographic_title":"Radiation Research"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"A radiation-induced bystander response, which is generally defined as a cellular response that is induced in nonirradiated cells that received bystander signals from directly irradiated cells within an irradiated cell population. In our earlier X-ray microbeam studies, bystander cell killing in normal human fibroblasts had a parabolic relationship to the irradiation dose. To elucidate the role of p53 in the bystander cell killing, the effects were assessed using human non-small cell lung cancer cells expressing wild-type or temperature-sensitive mutated p53. The surviving fraction of bystander wild-type p53 cells showed a parabolic relationship to the irradiation dose; survival was steeply reduced up to 0.45 Gy, recovered toward to 2 Gy, and remained at control levels up to 5 Gy. In contrast, in the mutated p53 cells at a nonpermissive temperature, the surviving fraction was steeply reduced up to 1 Gy and remained at the reduced level up to 5 Gy. When the mutated p53 cells were incubated at a permissive temperature, the decrease in the surviving fraction at 2 Gy was suppressed. The wild-type p53 cells were not only restrained in releasing bystander signals at 2 Gy, but were also resistant to the signals released by the mutated p53 cells. These results suggest that the X-ray-induced bystander cell killing depends on both the irradiation dose and the p53 status of the targeted cells and the bystander cells.","subitem_description_type":"Abstract"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1667/rr3010.1","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0033-7587","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tomita, Masanori"}],"nameIdentifiers":[{"nameIdentifier":"465165","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Maeda, Munetoshi"}],"nameIdentifiers":[{"nameIdentifier":"465166","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kobayashi, Katsumi"}],"nameIdentifiers":[{"nameIdentifier":"465167","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsumoto, Hideki"}],"nameIdentifiers":[{"nameIdentifier":"465168","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"冨田 雅典","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"465169","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小林 克己","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"465170","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松本 英樹","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"465171","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Dose Response of Soft X-Ray-Induced Bystander Cell Killing Affected by p53 Status.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Dose Response of Soft X-Ray-Induced Bystander Cell Killing Affected by p53 Status."}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-12-05"},"publish_date":"2013-12-05","publish_status":"0","recid":"46661","relation_version_is_last":true,"title":["Dose Response of Soft X-Ray-Induced Bystander Cell Killing Affected by p53 Status."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:49:07.355870+00:00"}