@article{oai:repo.qst.go.jp:00046658,
 author = {Hotta, Harumi and Masamoto, Kazuto and Uchida, Sae and Sekiguchi, Yuta and Takuwa, Hiroyuki and Kawaguchi, Hiroshi and Sudo, Ryo and Tanishita, Kazuo and Ito, Hiroshi and Kanno, Iwao and et.al and 堀田 晴美 and 正本 和人 and 内田 さえ and 関口 優太 and 田桑 弘之 and 川口 拓之 and 伊藤 浩 and 菅野 巖},
 issue = {9},
 journal = {Journal of Cerebral Blood Flow and Metabolism},
 month = {Jun},
 note = {To clarify mechanisms through which activation of the nucleus basalis of Meynert (NBM) increases cerebral cortical blood flow, we examined whether cortical parenchymal arteries dilate during NBM stimulation in anesthetized mice. We used two-photon microscopy to measure the diameter of single penetrating arteries at different depths (~800 μm, layers I to V) of the frontal cortex, and examined changes in the diameter during focal electrical stimulation of the NBM (0.5 ms at 30 to 50 μA and 50 Hz) and hypercapnia (3% CO2 inhalation). Stimulation of the NBM caused diameter of penetrating arteries to increase by 9% to 13% of the prestimulus diameter throughout the different layers of the cortex, except at the cortical surface and upper part of layer V, where the diameter of penetrating arteries increased only slightly during NBM stimulation. Hypercapnia caused obvious dilation of the penetrating arteries in all cortical layers, including the surface arteries. The diameters began to increase within 1 second after the onset of NBM stimulation in the upper cortical layers, and later in lower layers. Our results indicate that activation of the NBM dilates cortical penetrating arteries in a layer-specific manner in magnitude and latency, presumably related to the density of cholinergic nerve terminals from the NBM},
 pages = {1440--1447},
 title = {Layer-specific dilation of penetrating arteries induced by stimulation of the nucleus basalis of Meynert in the mouse frontal cortex},
 volume = {33},
 year = {2013}
}