@article{oai:repo.qst.go.jp:00046643,
 author = {Chai, H and Hazawa, Masaharu and Hosokawa, Y and Igarashi, J and Suga, H and Kashiwakura, Ikuo and 羽澤 勝治},
 issue = {8},
 journal = {Biological & Pharmaceutical Bulletin},
 month = {Nov},
 note = {The cytotoxicity of novel acridine-based N-acyl-homoserine lactone (AHL) analogs was investigated on the human oral squamous carcinoma cell line SAS. One analog induced G2/M phase arrest at 5.3-10.6 µM and induced polyploidy at a higher dose (21.2 µM). Importantly, treatment of SAS cells with a combination of the AHL analog and the Jun N-terminal kinase (JNK) inhibitor, SP600125, prevented mitosis and induced polyploidy. The AHL analog synergized with X-irradiation to inhibit clonogenic survival of SAS cells; however, its radiosensitizing effects were relative to not X-irradiation-induced apoptosis but mitotic failure following enhanced expression of Aurora A and B. These results suggest that the active AHL analog showed growth-suppressive and radiosensitizing effects, which involve polyploidy followed by G2/M accumulation and atypical cell death in the SAS cell line.},
 pages = {1257--63},
 title = {Novel acridine-based N-acyl-homoserine lactone analogs induce endoreduplication in the human oral squamous carcinoma cell line SAS.},
 volume = {35},
 year = {2012}
}