{"created":"2023-05-15T14:36:13.949683+00:00","id":46640,"links":{},"metadata":{"_buckets":{"deposit":"7a758549-5cbe-4766-b209-812464770d0e"},"_deposit":{"created_by":1,"id":"46640","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"46640"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00046640","sets":["1"]},"author_link":["464965","464964","464962","464963","464961","464960"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"61","bibliographicPageStart":"55","bibliographicVolumeNumber":"28","bibliographic_titles":[{"bibliographic_title":"Oncology Reports"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The acquisition of resistance to radiation has been a matter of concern in clinical cases. However, mechanisms underlying the acquisition of radiation resistance are yet to be elucidated. We established a radiation-resistant strain (Res-HL60 cells) from HL60 leukemic cells and investigated their response to radiation. Res-HL60 cells not only proliferated on the fifth day after radiation but also had a high survival rate in a clonogenic assay. Although Chk1 was activated in HL60 cells after irradiation, the expression levels of Chk1 in Res-HL60 cells decreased. There were few differences between the two cell lines with regard to Chk2 activity. Res-HL60 cells show prolonged G2/M arrest and an early decrease in the extent of DNA damage. However, inhibitors against ATM/ATR and DNA-dependent protein kinase (DNA-PK) both abrogated the radiation resistance capacity of the cells. These results reveal that radiation-resistant strains have a high repair capacity, and inhibition of the repair system at an early stage is an effective strategy in the second round of radiation therapy.","subitem_description_type":"Abstract"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.3892/or.2012.1771","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1021-335X","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hazawa, Masaharu"}],"nameIdentifiers":[{"nameIdentifier":"464960","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hosokawa Yoichiro"}],"nameIdentifiers":[{"nameIdentifier":"464961","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Monzen, Satoru"}],"nameIdentifiers":[{"nameIdentifier":"464962","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshino, Hironori"}],"nameIdentifiers":[{"nameIdentifier":"464963","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kashiwakura, Ikuo"}],"nameIdentifiers":[{"nameIdentifier":"464964","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"羽澤 勝治","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"464965","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Regulation of DNA damage response and cell cycle in radiation-resistant HL60 myeloid leukemia cells.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Regulation of DNA damage response and cell cycle in radiation-resistant HL60 myeloid leukemia cells."}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-11-26"},"publish_date":"2013-11-26","publish_status":"0","recid":"46640","relation_version_is_last":true,"title":["Regulation of DNA damage response and cell cycle in radiation-resistant HL60 myeloid leukemia cells."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:49:22.009646+00:00"}