@article{oai:repo.qst.go.jp:00046622,
 author = {Takayama, Yukihisa and Ohno, Tatsuya and Kishimoto, Riwa and Kato, Shingo and Yoneyama, Ryuichi and Kandatsu, Susumu and Tsujii, Hirohiko and Obata, Takayuki and 高山 幸久 and 大野 達也 and 岸本 理和 and 加藤 眞吾 and 米山 隆一 and 神立 進 and 辻井 博彦 and 小畠 隆行},
 issue = {3},
 journal = {Magnetic Resonance Imaging},
 month = {Sep},
 note = {[Purpose]
To assess the predictability of the response to radiotherapy of uterine carcinoma, this study retrospectively analyzed dynamic contrast-enhanced magnetic resonance images (DCE-MRI) taken before radiotherapy.
[Materials and Methods]
Forty-two patients with uterine carcinoma were studied, of whom 22 had adenocarcinoma and 20 had squamous cell carcinoma (SCC). In DCE-MRI analysis, two parameters, SIe and Rdown, were measured. SIe is a median value for the degree of signal intensity change in all selected pixels in the tumor at 1-2 min after contrast agent injection. Rdown is the ratio of the number of down-sloped pixels to that of all selected pixels 3-7 min after injection. The tumor volume reduction rate (TVRR) was measured by MRI-based volumetry in pre- and post-radiotherapy transverse T2-weighted images.
[Results]
Overall, TVRR was significantly correlated to both SIe (r=0.37, P=.015) and Rdown (r=0.73, P<.0001). In the separate patient groups, SIe but not Rdown was significantly different between the adenocarcinoma and SCC patients (t=3.64, P<.001). TVRR was not correlated to SIe in any group. TVRR was significantly correlated to Rdown in adenocarcinoma patients (r=0.78, P<.001) but not in SCC patients.
[Conclusion]
SIe may reflect differences in histological characteristics. Rdown may be useful for predicting the response to radiotherapy of uterine carcinoma.},
 pages = {370--376},
 title = {Prediction of early response to radiotherapy of uterine carcinoma with dynamic contrast-enhanced MR imaging using pixel analysis of MR perfusion imaging},
 volume = {27},
 year = {2008}
}