{"created":"2023-05-15T14:36:12.553038+00:00","id":46608,"links":{},"metadata":{"_buckets":{"deposit":"8b912532-b2d3-47a1-8d16-f98c4b2f7cb7"},"_deposit":{"created_by":1,"id":"46608","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"46608"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00046608","sets":["1"]},"author_link":["464622","464626","464624","464628","464623","464627","464629","464625"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"278","bibliographicPageStart":"273","bibliographicVolumeNumber":"18","bibliographic_titles":[{"bibliographic_title":"International Journal of Clinical Oncology"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"BACKGROUND: The purpose of this phase I trial of S-1 chemotherapy in combination with pelvic radiotherapy for locally recurrent rectal cancer was to determine the maximum tolerated dose (MTD), recommended dose (RD), and dose-limiting toxicity (DLT) of S-1.\n\\nMETHODS: We enrolled 9 patients between April 2005 and March 2009. Radiotherapy (total dose, 60 Gy in 30 fractions) was given to the gross local recurrent tumor and pelvic nodal metastases using three-dimensional radiotherapy planning. We administered oral S-1 twice a day on days 1-14 and 22-35 during radiotherapy. The dose of S-1 was initially 60 mg/m(2)/day and was increased to determine the MTD and RD for this regimen.\n\\nRESULTS: DLT appeared at dose level 2 (70 mg/m(2)/day) in 2 patients, who experienced grade 3 enterocolitis and consequently required suspension of S-1 administration for longer than 2 weeks. Hematological toxicity was mild and reversible. At the initial evaluation, complete regression and partial regression were seen in 1 patient (11%) and 2 patients (22%), respectively.\n\\nCONCLUSION: This phase I trial of S-1 chemotherapy with pelvic radiotherapy for locally recurrent rectal cancer revealed that the MTD for S-1 was 70 mg/m(2)/day and the RD was 60 mg/m(2)/day.","subitem_description_type":"Abstract"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1007/s10147-012-0375-y","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1341-9625","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Wada, Hitoshi"}],"nameIdentifiers":[{"nameIdentifier":"464622","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nemoto, Kenji"}],"nameIdentifiers":[{"nameIdentifier":"464623","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nomiya, Takuma"}],"nameIdentifiers":[{"nameIdentifier":"464624","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Murakami, Misako"}],"nameIdentifiers":[{"nameIdentifier":"464625","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suzuki, Motohisa"}],"nameIdentifiers":[{"nameIdentifier":"464626","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"et.al"}],"nameIdentifiers":[{"nameIdentifier":"464627","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"野宮 琢磨","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"464628","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鈴木 志恒","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"464629","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"A phase I trial of S-1 with concurrent radiotherapy in patients with locally recurrent rectal cancer.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A phase I trial of S-1 with concurrent radiotherapy in patients with locally recurrent rectal cancer."}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-10-17"},"publish_date":"2013-10-17","publish_status":"0","recid":"46608","relation_version_is_last":true,"title":["A phase I trial of S-1 with concurrent radiotherapy in patients with locally recurrent rectal cancer."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:49:44.861301+00:00"}