{"created":"2023-05-15T14:36:11.279686+00:00","id":46586,"links":{},"metadata":{"_buckets":{"deposit":"c1faf7d5-14ce-48a2-b6bb-fad28b048021"},"_deposit":{"created_by":1,"id":"46586","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"46586"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00046586","sets":["1"]},"author_link":["464354","464358","464348","464349","464352","464359","464357","464350","464360","464351","464355","464353","464356"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"8","bibliographicPageEnd":"1307","bibliographicPageStart":"1302","bibliographicVolumeNumber":"54","bibliographic_titles":[{"bibliographic_title":"Journal of Nuclear Medicine"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]-4-11C-methoxy-N-methylbenzamide (11C-ITMM) is a potential radioligand for mapping metabotropic glutamate receptor type 1 (mGluR1) in the brain by PET. The present study was performed to determine the safety, distribution, radiation dosimetry, and initial brain imaging of 11C-ITMM in healthy human subjects. Methods: The multiorgan biodistribution and radiation dosimetry of 11C-ITMM were assessed in 3 healthy human subjects, who underwent 2-h whole-body PET scans. Radiation dosimetry was estimated from the normalized number of disintegrations of source organs using the OLINDA/EXM program. Five healthy human subjects underwent 90-min dynamic 11C-ITMM scans of brain regions with arterial blood sampling. For anatomic coregistration, T1-weighted MR imaging was performed. Metabolites in plasma and urine samples were analyzed by high-performance liquid chromatography. 11C-ITMM uptake was assessed quantitatively using a 2-tissue-compartment model. Results: There were no serious adverse events in any of the subjects throughout the study period. 11C-ITMM PET demonstrated high uptake in the urinary bladder and gallbladder, indicating both urinary and fecal excretion of radioactivity. The absorbed dose (muGy/MBq) was highest in the urinary bladder wall (13.2+/-3.5), small intestine (9.8+/-1.7), and liver (9.1+/-2.0). The estimated effective dose for 11C-ITMM was 4.6+/-0.3muSv/MBq. 11C-ITMM showed a gradual increase of radioactivity in the cerebellar cortex. The total distribution volume in the brain regions ranged from 2.61+/-0.30 (cerebellar cortex) to 0.52+/-0.17 (pons), and the rank order of the corresponding total distribution volume of 11C-ITMM was cerebellar cortex > thalamus > frontal cortex > striatum ≈ pons, which was consistent with the known distribution of mGluR1 in the primate brain. The rate of 11C-ITMM metabolism in plasma was moderate: at 60 min after injection, 62.2%+/-8.2% of the radioactivity in plasma was intact parent compound. Conclusion: The initial findings of the present study indicated that 11C-ITMM PET is feasible for imaging of mGluR1 in the brain. The low effective dose will permit serial examinations in the same subjects.","subitem_description_type":"Abstract"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.2967/jnumed.113.119891","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0161-5505","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Toyohara, Jun"}],"nameIdentifiers":[{"nameIdentifier":"464348","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sakata, Muneyuki"}],"nameIdentifiers":[{"nameIdentifier":"464349","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Oda, Keiichi"}],"nameIdentifiers":[{"nameIdentifier":"464350","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishii, Kenji"}],"nameIdentifiers":[{"nameIdentifier":"464351","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ito, Kimiteru"}],"nameIdentifiers":[{"nameIdentifier":"464352","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hiura, Mikio"}],"nameIdentifiers":[{"nameIdentifier":"464353","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fujinaga, Masayuki"}],"nameIdentifiers":[{"nameIdentifier":"464354","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamasaki, Tomoteru"}],"nameIdentifiers":[{"nameIdentifier":"464355","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Ming-Rong"}],"nameIdentifiers":[{"nameIdentifier":"464356","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishiwata, Kiichi"}],"nameIdentifiers":[{"nameIdentifier":"464357","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤永 雅之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"464358","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山崎 友照","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"464359","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 明栄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"464360","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"lnitial Human PET Studies of Metabotropic Glutamate Receptor Type 1 Ligand 11C-lTMM","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"lnitial Human PET Studies of Metabotropic Glutamate Receptor Type 1 Ligand 11C-lTMM"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-08-23"},"publish_date":"2013-08-23","publish_status":"0","recid":"46586","relation_version_is_last":true,"title":["lnitial Human PET Studies of Metabotropic Glutamate Receptor Type 1 Ligand 11C-lTMM"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:49:59.706419+00:00"}