@article{oai:repo.qst.go.jp:00046564,
 author = {Takahara, Noriko and Saga, Tsuneo and Inubushi, Masayuki and Kusuhara, Hiroyuki and Ito, Sumito and Sugiyama, Yuichi and Fujibayashi, Yasuhisa and Seki, Chie and et.al and 佐賀 恒夫 and 犬伏 正幸 and 藤林 康久 and 関 千江},
 issue = {5},
 journal = {Nuclear Medicine and Biology},
 month = {Jul},
 note = {Introduction
Renal uptake of Tc-99m-MG3 involves organic anion transporter (OAT). Treatment with drugs showing OAT affinity might interfere with renal uptake of Tc-99m-MAG3, leading to misinterpretation in Tc-99m-MAG3. This study was conducted to discuss a possible drug interference with Tc-99m-MAG3 diagnosis on OAT sites.
Methods
Renal uptake and plasma clearance of Tc-99m-MAG3 were analyzed in healthy volunteers under control and OAT1 and OAT3 related drug treatment conditions. An in vitro uptake study using OAT1 or OAT3 expressing cells was also conducted.
Results
Both PAH and probenecid treatment induced delays in Tc-99m-MAG3 clearance from blood, and reductions in the renal uptake clearance. As a result, the normalized effective renal plasma flow estimated from Tc-99m-MAG3 clearance was significantly underestimated, whereas the glomerular filtration rate estimated from plasma creatinine levels was unchanged. The transport activity of Tc-99m-MAG3 was higher in OAT1-expressing cells than in OAT3-expressing cells.
Conclusion
Drugs with OAT1 affinity affect the renal uptake of Tc-99m-MAG3 and blood clearance. This might cause misinterpretation of functional diagnosis of the kidney using Tc-99m-MAG3.},
 pages = {643--650},
 title = {Drugs interacting with organic anion transporter-1 affect uptake of Tc-99m-mercaptoacetyl-triglycine (MAG3) in the human kidney: Therapeutic drug interaction in Tc-99m-MAG3 diagnosis of renal function and possible application of Tc-99m-MAG3 for drug development},
 volume = {40},
 year = {2013}
}