{"created":"2023-05-15T14:36:09.193201+00:00","id":46538,"links":{},"metadata":{"_buckets":{"deposit":"c54c790d-6cdd-474c-b3c4-0f19ba2c91c8"},"_deposit":{"created_by":1,"id":"46538","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"46538"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00046538","sets":["1"]},"author_link":["463814","463816","463817","463811","463815","463818","463813","463812","463810","463819"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"3634","bibliographicPageStart":"3625","bibliographicVolumeNumber":"13","bibliographic_titles":[{"bibliographic_title":"Sensors (Online Only URL:http://www.mdpi.org/sensors/)"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The study aimed to clarify the role of electric pulses in combination with\nchemotherapy on the viability of keratinocyte cell line HaCaT, in the context of its\napplication as a new therapeutic approach for psoriasis. The data show that electroporation\nof HaCaT cells in combination with rifampicin induces cytoskeleton disruption and\nincreases permeability of cell monolayer due to cell-cell junctions interruption, visualized\nby fluorescent imaging of E-cadherin and actin integrity. This was accompanied with\nsynergistic reduction of cell viability. The study proposes a new opportunity for more effective\nskin treatment than chemotherapy. The future application of this electrochemotherapeutic\napproach for combined local treatment of psoriasis may have serous benefits because of a\nhigh possibility to avoid side-effects of conventional chemotherapy.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1424-8220","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Nikolova, Biliana"}],"nameIdentifiers":[{"nameIdentifier":"463810","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhelev, Zhivko"}],"nameIdentifiers":[{"nameIdentifier":"463811","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Bakalova-Zheleva, Rumiana"}],"nameIdentifiers":[{"nameIdentifier":"463812","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Aoki, Ichio"}],"nameIdentifiers":[{"nameIdentifier":"463813","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Saga, Tsuneo"}],"nameIdentifiers":[{"nameIdentifier":"463814","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"et.al"}],"nameIdentifiers":[{"nameIdentifier":"463815","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ｚｈｅｌｅｖ Ｚｈｉｖｋｏ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"463816","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"バカロバ ルミアナ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"463817","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"青木 伊知男","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"463818","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐賀 恒夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"463819","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Fluorescent Imaging for Assessment of the Effect of Combined Application of Electroporation and Rifampicin on HaCaT Cells as a New Therapeutic Approach for Psoriasis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Fluorescent Imaging for Assessment of the Effect of Combined Application of Electroporation and Rifampicin on HaCaT Cells as a New Therapeutic Approach for Psoriasis"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-04-26"},"publish_date":"2013-04-26","publish_status":"0","recid":"46538","relation_version_is_last":true,"title":["Fluorescent Imaging for Assessment of the Effect of Combined Application of Electroporation and Rifampicin on HaCaT Cells as a New Therapeutic Approach for Psoriasis"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:50:34.642677+00:00"}