@article{oai:repo.qst.go.jp:00046507,
 author = {Ohno, Tatsuya and Huy, Quoc Thinh Dang and Kato, Shingo and Devi, Beena C.R. and Thanh, Tung Ngo and Thephamongkhol, Kullathorn and Joy, C Calaguas Miriam and Juying, Zhou and Chansilpa, Yaowalak and Nana, Supriana and Erawati, Dyah and Akhter, Banu Parvin and Koo, Chul Cho and Kobayashi, Kunihiko and Nakano, Takashi and Tsujii, Hirohiko and 大野 達也 and 加藤 眞吾 and 中野 隆史 and 辻井 博彦},
 issue = {3},
 journal = {Journal of Radiation Research},
 month = {Nov},
 note = {The purpose of this study was to evaluate the efficacy and toxicity of radiotherapy concurrently with weekly cisplatin, followed by adjuvant chemotherapy, for the treatment of N2–3 nasopharyngeal cancer (NPC) in Asian countries, especially regions of South and Southeast Asian countries where NPC is endemic. Between 2005 and 2009, 121 patients with NPC (T1–4 N2–3 M0) were registered from Vietnam, Malaysia, Indonesia, Thailand, The Philippines, China and Bangladesh. Patients were treated with 2D radiotherapy concurrently with weekly cisplatin (30 mg/m 2), followed by adjuvant chemotherapy, consisting of cisplatin (80 mg/m2 on Day 1) and fluorouracil (800 mg/m2 on Days 1–5) for 3 cycles. Of the 121 patients, 56 patients (46%) required interruption of RT. The reasons for interruption of RT were acute non-hematological toxicities such as mucositis, pain and dermatitis in 35 patients, hematological toxicities in 11 patients, machine break-down in 3 patients, poor general condition in 2 patients, and others in 8 patients. Of the patients, 93% completed at least 4 cycles of weekly cisplatin during radiotherapy, and 82% completed at least 2 cycles of adjuvant chemotherapy. With a median follow-up time of 46 months for the surviving 77 patients, the 3-year locoregional control, distant metastasis-free survival and overall survival rates were 89%, 74% and 66%, respectively. No treatment-related deaths occurred. Grade 3–4 toxicities of mucositis, nausea/vomiting and leukopenia were observed in 34%, 4% and 4% of the patients, respectively. In conclusion, further improvement in survival and locoregional control is necessary, although our regimen showed acceptable toxicities.},
 pages = {467--473},
 title = {Radiotherapy concurrently with weekly cisplatin, followed by adjuvant chemotherapy, for N2-3 nasopharyngeal cancer: a multicenter trial of the Forum for Nuclear Cooperation in Asia},
 volume = {54},
 year = {2012}
}