{"created":"2023-05-15T14:36:07.527867+00:00","id":46500,"links":{},"metadata":{"_buckets":{"deposit":"0ab2fc13-ff5b-466c-adee-10f63d8fd184"},"_deposit":{"created_by":1,"id":"46500","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"46500"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00046500","sets":["1"]},"author_link":["463384","463373","463383","463386","463380","463382","463372","463376","463375","463365","463370","463385","463378","463379","463371","463368","463374","463377","463366","463367","463369","463381"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"1140","bibliographicPageStart":"1134","bibliographicVolumeNumber":"85","bibliographic_titles":[{"bibliographic_title":"International Journal of Radiation Oncology Biology Physics"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Purpose: The risk of developing secondary cancer after radiotherapy, especially after treatment of childhood cancers, remains a matter of concern. The high biological effects of carbon-ion radiation have enabled powerful radiotherapy, yet the approach is commonly restricted to the treatment of adults. Susceptibility of the fetus to particle radiation-induced cancer is also unclear. The present study is aimed to investigate the effect of carbon-ion irradiation in childhood on breast carcinogenesis.\nMethods and Materials: We irradiated female Sprague-Dawley rats of various ages (embryonic days 3, 13 and 17, and 1, 3, 7 and 15 weeks after birth) with 137Cs gamma rays or a 290-MeV/u monoenergetic carbon-ion beam (linear energy transfer, 13 keV/um). All animals were screened weekly for mammary carcinoma by palpation until they were 90 weeks old. \nResults: Irradiation of fetal and mature (15-week-old) rats with either radiation source at a dose of 0.2 or 1 Gy did not substantially increase the hazard ratio compared to the non-irradiated group. Dose responses (0.2-2.0 Gy) to gamma rays were similar among the groups of rats irradiated 1, 3 and 7 weeks after birth. The effect of carbon ions increased along with the age at the time of irradiation, indicating relative biological effectiveness values of 0.2 [-0.3, 0.7], 1.3 [1.0, 1.6] and 2.8 [1.8, 3.9] (mean and 95% confidence interval) for animals that were 1, 3 and 7 weeks of age, respectively. \nConclusions: Our findings imply that carbon-ion therapy may be associated with a risk of secondary breast cancer in humans, the extent of which may depend on the age of the patient at the time of irradiation.","subitem_description_type":"Abstract"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.ijrobp.2012.08.035","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://www.redjournal.org/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.redjournal.org/","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0360-3016","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Imaoka, Tatsuhiko"}],"nameIdentifiers":[{"nameIdentifier":"463365","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nishimura, Mayumi"}],"nameIdentifiers":[{"nameIdentifier":"463366","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Daino, Kazuhiro"}],"nameIdentifiers":[{"nameIdentifier":"463367","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kokubo, Toshiaki"}],"nameIdentifiers":[{"nameIdentifier":"463368","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Doi, Kazutaka"}],"nameIdentifiers":[{"nameIdentifier":"463369","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Iizuka, Daisuke"}],"nameIdentifiers":[{"nameIdentifier":"463370","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nishimura, Yukiko"}],"nameIdentifiers":[{"nameIdentifier":"463371","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okutani, Tomomi"}],"nameIdentifiers":[{"nameIdentifier":"463372","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takabatake, Masaru"}],"nameIdentifiers":[{"nameIdentifier":"463373","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kakinuma, Shizuko"}],"nameIdentifiers":[{"nameIdentifier":"463374","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shimada, Yoshiya"}],"nameIdentifiers":[{"nameIdentifier":"463375","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"今岡 達彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"463376","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"西村 まゆみ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"463377","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"臺野 和広","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"463378","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小久保 年章","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"463379","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"土居 主尚","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"463380","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"飯塚 大輔","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"463381","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"西村 由希子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"463382","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"奥谷 倫未","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"463383","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高畠 賢","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"463384","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"柿沼 志津子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"463385","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田 義也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"463386","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Influence of age on the relative biological effectiveness of carbon ion radiation for induction of rat mammary carcinoma.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Influence of age on the relative biological effectiveness of carbon ion radiation for induction of rat mammary carcinoma."}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-03-01"},"publish_date":"2013-03-01","publish_status":"0","recid":"46500","relation_version_is_last":true,"title":["Influence of age on the relative biological effectiveness of carbon ion radiation for induction of rat mammary carcinoma."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:51:01.647982+00:00"}