{"created":"2023-05-15T14:36:07.209866+00:00","id":46493,"links":{},"metadata":{"_buckets":{"deposit":"4bf845fa-bb17-485e-b47b-0bf8e4f982aa"},"_deposit":{"created_by":1,"id":"46493","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"46493"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00046493","sets":["1"]},"author_link":["463296","463294","463292","463285","463282","463281","463291","463283","463287","463288","463293","463295","463290","463289","463284","463286","463297"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"22","bibliographicPageEnd":"7554","bibliographicPageStart":"7543","bibliographicVolumeNumber":"57","bibliographic_titles":[{"bibliographic_title":"Physics in Medicine and Biology"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"In carbon ion radiotherapy there is an urgent clinical need to develop objective\ntools for the conversion of relative biological effectiveness (RBE)-weighted\ndoses based on different models. In this work we introduce a clinically oriented\nmethod to compare NIRS-based and LEM-based GyE systems, minimizing\ndifferences in physical dose distributions between treatment plans. Carbon ion\nplans were optimized on target volumes of cubic and spherical shapes, for RBEweighted dose prescription levels ranging from 3.6 to 4.4 GyE. Plans were\ncalculated for target sizes from 4 to 12 cm defining three beam geometries:\nsingle beam, opposed beam and orthogonal beam configurations. The two\ntreatment planning systems currently employed in clinical practice were used,\nproviding the NIRS-based and LEM-based GyE calculations. Physical dose\ndistributions of NIRS-based and LEM-based treatment plans were compared.\nLEM-based prescription doses that minimize differences in physical dose\ndistributions between the two systems were found. These doses were compared\nwith the mean RBE-weighted dose obtained with a Monte Carlo code (FLUKA)\ninterfaced with LEM I. In the investigated dose range, LEM-based RBEweighted\nprescription doses, that minimize differences with NIRS plans, should\nbe higher than NIRS reported prescription doses. The optimal dose depends on\ntarget size, shape and position, number of beams and dose level. The opposed\nbeam configuration resulted in the smallest average prescription dose difference\n(0.45 +/- 0.09 GyE). The second approach of recalculating NIRS RBE-weighted\ndose with a Monte Carlo code interfaced with LEM resulted in no significant\ndifference with the results obtained from the planning study. The delivery of a\nvoxel by voxel iso-effective plan, if different RBE models are employed, is not\nfeasible; it is however possible to minimize differences in a treatment plan with\nthe simple approach presented here. Dose prescription ultimately represents a\nclinical task under the responsibility of the radiation oncologist, the presented\nanalysis intends to be a quantitative and objective way to assist the clinical\ndecision.","subitem_description_type":"Abstract"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1088/0031-9155/57/22/7543","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0031-9155","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Fossati, Piero"}],"nameIdentifiers":[{"nameIdentifier":"463281","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Molinelli, Silvia"}],"nameIdentifiers":[{"nameIdentifier":"463282","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsufuji, Naruhiro"}],"nameIdentifiers":[{"nameIdentifier":"463283","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mizoe, Junetsu"}],"nameIdentifiers":[{"nameIdentifier":"463284","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hasegawa, Azusa"}],"nameIdentifiers":[{"nameIdentifier":"463285","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Imai, Reiko"}],"nameIdentifiers":[{"nameIdentifier":"463286","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kamada, Tadashi"}],"nameIdentifiers":[{"nameIdentifier":"463287","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsujii, Hirohiko"}],"nameIdentifiers":[{"nameIdentifier":"463288","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"et.al"}],"nameIdentifiers":[{"nameIdentifier":"463289","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ｆｏｓｓａｔｉ Ｐｉｅｒｏ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"463290","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ｍｏｌｉｎｅｌｌｉ Ｓｉｌｖｉａ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"463291","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松藤 成弘","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"463292","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"溝江 純悦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"463293","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"長谷川 安都佐","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"463294","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"今井 礼子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"463295","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鎌田 正","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"463296","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻井 博彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"463297","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Dose prescription in carbon ion radiotherapy: a planning study to compare NIRS and LEM approaches with a clinically-oriented strategy","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Dose prescription in carbon ion radiotherapy: a planning study to compare NIRS and LEM approaches with a clinically-oriented strategy"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-02-16"},"publish_date":"2013-02-16","publish_status":"0","recid":"46493","relation_version_is_last":true,"title":["Dose prescription in carbon ion radiotherapy: a planning study to compare NIRS and LEM approaches with a clinically-oriented strategy"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:51:07.854322+00:00"}