@article{oai:repo.qst.go.jp:00046481,
 author = {Iwata, Shintaro and Yonemoto, Tsukasa and Ishii, Takeshi and Kumagai, Kyoya and Imai, Reiko and Hagiwara, Yoko and Kamada, Tadashi and Tatezaki, Shinichiro and 今井 礼子 and 鎌田 正},
 journal = {International Journal of Clinical Oncology},
 month = {Oct},
 note = {Background 
Treatment for unresectable Ewing's sarcoma family of tumors (ESFT) is a formidable challenge because of its high tendency for local and distant failure. Recently, carbon-ion radiotherapy (CIRT) has been applied to unre- sectable bone and soft tissue sarcoma. Additionally, high- dose chemotherapy (HDC) with stem cell rescue has been used to improve the survival of patients with relapsed ESFT. Here we report our experience with CIRT and HDC in the treatment of unresectable ESFT.
\nMethods 
Five unresectable ESFT patients including 4 who underwent CIRT and HDC and one who underwent
CIRT from 1999-2009 were retrospectively studied. After neoadjuvant chemotherapy, CIRT was conducted at the National Institute of Radiological Sciences in Chiba as local therapy. Consecutively, we employed HDC including busulfan, melphalan, and thiotepa with stem cell rescue.
\nResults 
Two patients showed tumor shrinkage after
CIRT, including 1 patient who achieved partial response.},
 title = {Efficacy of carbon-ion radiotherapy and high-dose chemotherapy for patients with unresectable Ewing's sarcoma family of tumors},
 year = {2012}
}