{"created":"2023-05-15T14:36:06.607127+00:00","id":46480,"links":{},"metadata":{"_buckets":{"deposit":"f933098c-9e25-4c13-b664-d78b87dca7a9"},"_deposit":{"created_by":1,"id":"46480","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"46480"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00046480","sets":["1"]},"author_link":["463138","463140","463142","463141","463139","463143","463145","463137","463146","463135","463148","463144","463136","463147"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"51","bibliographicPageStart":"45","bibliographicVolumeNumber":"54","bibliographic_titles":[{"bibliographic_title":"Journal of Radiation Research"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Existence of adaptive response (AR) was previously demonstrated in C57BL/6J mice. Irradiations were \nperformed by delivering a priming low dose of X-rays (0.50 Gy) in combination with a challenge high dose \nof accelerated carbon or neon ion particles. AR was characterized by significantly decreased mortality in \nthe 30-day survival test. This mouse AR model (Yonezawa Effect) was originally established by using X-rays \nas both the priming and challenge irradiations. The underlying mechanism was due to radio-resistance oc- \ncurring in blood-forming tissues. In this study, we verified the existence of AR and further investigated re- \nsidual damage in the hematopoietic system in surviving animals. Results showed that the priming low dose \nof X-rays could relieve the detrimental effects on the hematopoietic system. We observed both an improve- \nment in the blood platelet count and the ratio of polychromatic erythrocytes (PCEs) to the sum of PCEs and \nnormochromatic erythrocytes (NCEs) and a marked reduction of the incidences of micronucleated PCEs \nand micronucleated NCEs. These findings suggest that the priming low dose of low linear energy transfer \n(LET) X-rays induced a protective effect on the hematopoietic system, which may play an important role in \nboth rescue from acute lethal damage (mouse killing) and prevention of late detrimental consequences (re- \nsidual anhematopoiesis and delayed genotoxic effects) caused by exposure to a high challenge dose from \nlow-LET (X-ray) or high-LET (carbon and neon ion) irradiations. These findings provide new knowledge \nof the characterization of the Yonezawa Effect by providing new insight into the mechanistic study of AR \nin vivo.","subitem_description_type":"Abstract"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1093/jrr/rrs077","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0449-3060","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Bing, Wang"}],"nameIdentifiers":[{"nameIdentifier":"463135","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tanaka, Kaoru"}],"nameIdentifiers":[{"nameIdentifier":"463136","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ninomiya, Yasuharu"}],"nameIdentifiers":[{"nameIdentifier":"463137","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Maruyama, Kouichi"}],"nameIdentifiers":[{"nameIdentifier":"463138","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Vares, Guillaume"}],"nameIdentifiers":[{"nameIdentifier":"463139","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Eguchi-Kasai, Kiyomi"}],"nameIdentifiers":[{"nameIdentifier":"463140","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nenoi, Mitsuru"}],"nameIdentifiers":[{"nameIdentifier":"463141","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"王 冰","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"463142","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田中 薫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"463143","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"二宮 康晴","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"463144","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"丸山 耕一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"463145","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ｇｕｉｌｌａｕｍｅ Ｖａｒｅｓ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"463146","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"笠井 清美","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"463147","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"根井 充","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"463148","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Relieved residual damage in the hematopoietic system of mice rescued  by radiation-induced adaptive response (Yonezawa Effect)","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Relieved residual damage in the hematopoietic system of mice rescued  by radiation-induced adaptive response (Yonezawa Effect)"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-01-15"},"publish_date":"2013-01-15","publish_status":"0","recid":"46480","relation_version_is_last":true,"title":["Relieved residual damage in the hematopoietic system of mice rescued  by radiation-induced adaptive response (Yonezawa Effect)"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:51:18.468368+00:00"}