{"created":"2023-05-15T14:36:05.609646+00:00","id":46458,"links":{},"metadata":{"_buckets":{"deposit":"0e87c9d5-2487-4d21-87fa-f5040636796d"},"_deposit":{"created_by":1,"id":"46458","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"46458"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00046458","sets":["1"]},"author_link":["462875","462881","462886","462888","462884","462883","462892","462874","462882","462876","462878","462889","462877","462891","462879","462887","462890","462880","462885","462873"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"89","bibliographicPageStart":"84","bibliographicVolumeNumber":"23","bibliographic_titles":[{"bibliographic_title":"脳循環代謝 = Cerebral Blood Flow and Metabolism : 日本脳循環代謝学会機関誌"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"二光子レーザー顕微鏡法を用いたマウス慢性頭窓法による大脳皮質微小血管及びアストロサイトの反復ライブイメージング法について報告する．血管内皮細胞Tie2受容体に緑色蛍光タンパクを発現させた遺伝子組み換えマウスを2群に分け，慢性頭窓法を施し，中大脳動脈永久閉塞による脳虚血または酸素濃度8％環境飼育による低酸素負荷モデルを作製し，脳血管及びアストロサイトの形態を同一部位において反復観察した．脳虚血モデルでは，内腔が閉塞した毛細血管において血管の退縮，また血流が維持された周辺部において血管内皮細胞とアストロサイトの肥大が認められた．一方，低酸素負荷に対しては，既存毛細血管からの血管の伸長及び血管ネットワークの新生が認められた．本実験モデルは，脳内血管新生における血管内皮細胞の発芽，伸長，既存血管との融合，及び新生血管の成熟に関する細胞メカニズムの解明において有用である事が示された．","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0915-9401","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only 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