@article{oai:repo.qst.go.jp:00046449, author = {Nagatsu, Koutarou and Suzuki, Hisashi and Fukada, Masami and Minegishi, Katsuyuki and Tsuji, Atsushi and Fukumura, Toshimitsu and 永津 弘太郎 and 鈴木 寿 and 深田 正美 and 峯岸 克行 and 辻 厚至 and 福村 利光}, issue = {8}, journal = {Nuclear Medicine and Biology}, month = {Nov}, note = {Introduction: As the use of metallic radionuclides increases, so does the demand for a simple production method. In this study, we demonstrated an in situ target processing concept for automated metallic radionuclide production without the use of any robotic device. Methods: An alumina ceramic vessel for a vertical irradiation system was designed and developed. The ceramic vessel was evaluated by the production of Zr-89 using an yttrium powder target. The irradiated Y was dissolved remotely in HCl in the ceramic vessel and transferred as a solution to a hotcell through a Teflon tube. The crude Zr-89 was then purified by an automated apparatus. The Zr-89 was eluted with 100 muL of oxalic acid (solution) as the final product. Results: The ceramic vessel gave a sufficient yield of Zr-89 (57+/-11 MBq/muAh), showed good operability, and could be reused up to 10 times. With nominal irradiation (10 muAx2 h) in ~90 muL, the product (~940 MBq) was obtained with N99.9% radionuclidic purity. Conclusion: The combination of the ceramic vessel and vertical irradiation has great potential for the remote production of various metallic radionuclides.}, pages = {1281--1285}, title = {An alumina ceramic target vessel for the remote production of metallic radioinuclides by in situ target dissolution.}, volume = {39}, year = {2012} }