@article{oai:repo.qst.go.jp:00046437,
 author = {Hatori, Akiko and Yui, Joji and Yamasaki, Tomoteru and Xie, Lin and Kumata, Katsushi and Fujinaga, Masayuki and Yoshida, Yuichirou and Ogawa, Masanao and Nengaki, Nobuki and Kawamura, Kazunori and Fukumura, Toshimitsu and Zhang, Ming-Rong and 羽鳥 晶子 and 由井 譲二 and 山崎 友照 and 謝 琳 and 熊田 勝志 and 藤永 雅之 and 吉田 勇一郎 and 小川 政直 and 念垣 信樹 and 河村 和紀 and 福村 利光 and 張 明栄},
 issue = {9},
 journal = {PLoS ONE (Online only:URL:http://www.plosone.org)},
 month = {Sep},
 note = {Purpose: The translocator protein (18 kDa) (TSPO) is highly expressed on the bronchial and bronchiole epithelium,submucosal glands in intrapulmonary bronchi, pneumocytes and alveolar macrophages in human lung. This study aimed to perform positron emission tomography (PET) imaging of lung inflammation with [18F]FEDAC, a specific TSPO radioligand, and to determine cellular sources enriching TSPO expression in the lung.
Methods: An acute lung injury model was prepared by intratracheal administration of lipopolysaccharide (LPS) to rat. Uptake of radioactivity in the rat lungs was measured with small-animal PET after injection of [18F]FEDAC. Presence of TSPO
was examined in the lung tissue using Western blot and immunohistochemical assays.
Results: The uptake of [18F]FEDAC increased in the lung with the progress of inflammation by treatment with LPS. Pretreatment with a TSPO-selective ligand PK11195 showed a significant decrease in the lung uptake of [18F]FEDAC due to
competitive binding to TSPO. TSPO expression was elevated in the inflamed lung section and its level responded to the [18F]FEDAC uptake and severity of inflammation. Increase of TSPO expression was mainly found in the neutrophils and
macrophages of inflamed lungs.
Conclusion: From this study we conclude that PET with [18F]FEDAC may be a useful tool for imaging TSPO expression and evaluating progress of lung inflammation. Study on human lung using [18F]FEDAC-PET is promising.},
 pages = {1--8},
 title = {PET Imaging of Lung Inflammation with [18F]FEDAC,  a Radioligand for Translocator Protein (18 kDa)},
 volume = {7},
 year = {2012}
}