{"created":"2023-05-15T14:36:04.354514+00:00","id":46429,"links":{},"metadata":{"_buckets":{"deposit":"b0545a8b-c791-4b88-8cd6-9b9e20b55920"},"_deposit":{"created_by":1,"id":"46429","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"46429"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00046429","sets":["1"]},"author_link":["462504","462507","462500","462513","462509","462508","462505","462506","462512","462502","462503","462510","462511","462514","462501","462499"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"418","bibliographicPageStart":"413","bibliographicVolumeNumber":"159","bibliographic_titles":[{"bibliographic_title":"Journal of Controlled Release"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Active targeting by monoclonal antibodies (mAbs) combined with nanosize superparamagnetic iron oxide (SPIO) is a promising technology for magnetic resonance imaging (MRI) diagnosis. However, the clinical applicability of this technology has not been investigated using appropriate controls. It is important to evaluate the targeting technology using widely used clinical 1.5-Tesla MRI in addition to the high-Tesla experimental MRI. In this study, we measured mAb-conjugated dextran-coated SPIO nanoparticles (CMDM) in vivo using clinical 1.5-Tesla MRI. MRI of tumor-bearing mice was performed using a simple comparison between positive and negative tumors derived from the same genetic background in each mouse. The system provided significant tumor-targeting specificity of the target tumor. To the best of our knowledge, this is the first report on the specific detection of target tumors by mAb-conjugated SPIO using clinical 1.5-Tesla MRI. Our observations provide clues for reliable active targeting using mAb-conjugated SPIO in clinical applications.","subitem_description_type":"Abstract"}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://dx.doi.org/10.1016/j.jconrel.2012.01.023,"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://dx.doi.org/10.1016/j.jconrel.2012.01.023,","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0168-3659","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Koyama, Takayoshi"}],"nameIdentifiers":[{"nameIdentifier":"462499","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Minemoto, Yuzuru"}],"nameIdentifiers":[{"nameIdentifier":"462500","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nohara, Satoshi"}],"nameIdentifiers":[{"nameIdentifier":"462501","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shibata, Sayaka"}],"nameIdentifiers":[{"nameIdentifier":"462502","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hasegawa, Masakatsu"}],"nameIdentifiers":[{"nameIdentifier":"462503","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kono, Kenji"}],"nameIdentifiers":[{"nameIdentifier":"462504","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Aoki, Ichio"}],"nameIdentifiers":[{"nameIdentifier":"462505","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishizaka, Yukihito"}],"nameIdentifiers":[{"nameIdentifier":"462506","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"et.al"}],"nameIdentifiers":[{"nameIdentifier":"462507","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小山 貴芳","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"462508","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"峯本 譲","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"462509","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"野原 聡","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"462510","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"柴田 さやか","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"462511","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"長谷川 正勝","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"462512","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"青木 伊知男","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"462513","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"石坂 幸人","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"462514","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Evaluation of selective tumor detection by clinical magnetic resonance imaging using antibody-conjugated superparamagnetic iron oxide","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Evaluation of selective tumor detection by clinical magnetic resonance imaging using antibody-conjugated superparamagnetic iron oxide"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-10-31"},"publish_date":"2012-10-31","publish_status":"0","recid":"46429","relation_version_is_last":true,"title":["Evaluation of selective tumor detection by clinical magnetic resonance imaging using antibody-conjugated superparamagnetic iron oxide"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:51:54.863242+00:00"}