{"created":"2023-05-15T14:36:02.803691+00:00","id":46393,"links":{},"metadata":{"_buckets":{"deposit":"e89a9f44-ef42-48a6-8bcc-61b05acaedb5"},"_deposit":{"created_by":1,"id":"46393","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"46393"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00046393","sets":["1"]},"author_link":["462168","462167","462166"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"90","bibliographicPageStart":"85","bibliographicVolumeNumber":"33","bibliographic_titles":[{"bibliographic_title":"Journal of Cerebral Blood Flow and Metabolism"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We have developed a feedback-controlled bolus plus infusion (FC-B/I) method for monitoring the interaction between positron\nemission tomography (PET) ligands and their specific target molecules with PET. The usefulness of the FC-B/I method was evaluated\nby the direct interaction between [11C]raclopride, a dopamine D2 receptor (D2R) ligand, and cold raclopride (10 and 100 mg/kg) in\nthe brains of conscious monkeys. The present results demonstrated that the FC-B/I method could achieve the equilibrium state of\n[11C]raclopride in the striatum of monkey brain, and also that the cold raclopride-induced reduction of [11C]raclopride binding to\nD2R was observed in a dose-dependent manner. Good correlations of distribution volume ratio of the striatum to cerebellum\nbetween the conventional bolus plus infusion (B/I) method and the FC-B/I method as well as between the conventional bolus\ninjection method and the FC-B/I method were observed. These results indicated that the system could be a useful tool for the\nevaluation of interaction between drug candidates and their target molecules like enzymes, receptors, and transporters by using of\ntheir specific PET ligands.","subitem_description_type":"Abstract"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1038/jcbfm.2012.134","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0271-678X","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kimura, Yuichi"}],"nameIdentifiers":[{"nameIdentifier":"462166","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"et.al"}],"nameIdentifiers":[{"nameIdentifier":"462167","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"木村 裕一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"462168","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Feedback-controlled bolus plus infusion (FC-B/I) method for quantitative drug assessment in living brain with PET","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Feedback-controlled bolus plus infusion (FC-B/I) method for quantitative drug assessment in living brain with PET"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-09-19"},"publish_date":"2012-09-19","publish_status":"0","recid":"46393","relation_version_is_last":true,"title":["Feedback-controlled bolus plus infusion (FC-B/I) method for quantitative drug assessment in living brain with PET"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:52:21.686264+00:00"}