@article{oai:repo.qst.go.jp:00046393,
 author = {Kimura, Yuichi and et.al and 木村 裕一},
 issue = {1},
 journal = {Journal of Cerebral Blood Flow and Metabolism},
 month = {Sep},
 note = {We have developed a feedback-controlled bolus plus infusion (FC-B/I) method for monitoring the interaction between positron
emission tomography (PET) ligands and their specific target molecules with PET. The usefulness of the FC-B/I method was evaluated
by the direct interaction between [11C]raclopride, a dopamine D2 receptor (D2R) ligand, and cold raclopride (10 and 100 mg/kg) in
the brains of conscious monkeys. The present results demonstrated that the FC-B/I method could achieve the equilibrium state of
[11C]raclopride in the striatum of monkey brain, and also that the cold raclopride-induced reduction of [11C]raclopride binding to
D2R was observed in a dose-dependent manner. Good correlations of distribution volume ratio of the striatum to cerebellum
between the conventional bolus plus infusion (B/I) method and the FC-B/I method as well as between the conventional bolus
injection method and the FC-B/I method were observed. These results indicated that the system could be a useful tool for the
evaluation of interaction between drug candidates and their target molecules like enzymes, receptors, and transporters by using of
their specific PET ligands.},
 pages = {85--90},
 title = {Feedback-controlled bolus plus infusion (FC-B/I) method for quantitative drug assessment in living brain with PET},
 volume = {33},
 year = {2012}
}