{"created":"2023-05-15T14:36:01.812611+00:00","id":46370,"links":{},"metadata":{"_buckets":{"deposit":"6cf7db14-c3d1-430a-ac9f-8b4e2d13ad91"},"_deposit":{"created_by":1,"id":"46370","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"46370"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00046370","sets":["1"]},"author_link":["461918","461917","461911","461908","461926","461928","461921","461909","461925","461922","461929","461927","461915","461914","461912","461923","461920","461924","461919","461910","461913","461916"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"8","bibliographicPageEnd":"755","bibliographicPageStart":"750","bibliographicVolumeNumber":"105","bibliographic_titles":[{"bibliographic_title":"Journal of Surgical Oncology"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"BACKGROUND: Carbon-ion radiotherapy (CIR) has been under development. We report the results of a phase I/II clinical trial of preoperative CIR for esophageal squamous cell carcinoma (ESCC).\nMETHODS: Thirty-one thoracic ESCC patients were enrolled. They were first treated with CIR. The radiation dose was escalated from the initial dose of 28.8 GyE up to 36.8. Four to 8 weeks after CIR followed by clinical evaluation of the therapy, surgery was performed. Thereafter, a pathological evaluation was made.\nRESULTS: Acute toxicity was not seen except in one case (3.2%), and there were no late toxicities. Throughout the study period, there were no cases of withdrawal due to the effects of preoperative CIR. Twelve out of 31 (38.7%) patients achieved a clinical complete response (CR) and 13 patients (41.9%) achieved a partial response. Twelve out of 31 patients (38.7%) achieved a pathological CR. The overall 1-, 3-, and 5-year survival rates in the stage I cases were 91%, 81%, and 61%, and was 100%, 85%, and 77% for the stage II, and 71%, 43%, and 29% for the stage III cases, respectively.\nCONCLUSIONS: CIR showed strong local tumor control and is highly effective as a neoadjuvant therapy without severe adverse events.","subitem_description_type":"Abstract"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1002/jso.22127","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0022-4790","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Akutsu, Yasunori"}],"nameIdentifiers":[{"nameIdentifier":"461908","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yasuda, Shigeo"}],"nameIdentifiers":[{"nameIdentifier":"461909","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nagata, Matsuo"}],"nameIdentifiers":[{"nameIdentifier":"461910","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Izumi, Yousuke"}],"nameIdentifiers":[{"nameIdentifier":"461911","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okazumi, Shin-ichi"}],"nameIdentifiers":[{"nameIdentifier":"461912","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shimada, Hideaki"}],"nameIdentifiers":[{"nameIdentifier":"461913","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakatani, Yukio"}],"nameIdentifiers":[{"nameIdentifier":"461914","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsujii, Hirohiko"}],"nameIdentifiers":[{"nameIdentifier":"461915","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kamada, Tadashi"}],"nameIdentifiers":[{"nameIdentifier":"461916","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamada, Shigeru"}],"nameIdentifiers":[{"nameIdentifier":"461917","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsubara, Hisahiro"}],"nameIdentifiers":[{"nameIdentifier":"461918","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"阿久津 泰典","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"461919","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安田 茂雄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"461920","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"永田 松夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"461921","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"出江 洋介","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"461922","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岡住 慎一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"461923","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田 英昭","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"461924","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中谷 行雄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"461925","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻井 博彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"461926","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鎌田 正","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"461927","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山田 滋","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"461928","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松原 久裕","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"461929","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"A Phase I/II Clinical Trial of Preoperative Short-Course Carbon-Ion Radiotherapy for Patients With Squamous Cell Carcinoma of the Esophagus","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A Phase I/II Clinical Trial of Preoperative Short-Course Carbon-Ion Radiotherapy for Patients With Squamous Cell Carcinoma of the Esophagus"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-07-31"},"publish_date":"2012-07-31","publish_status":"0","recid":"46370","relation_version_is_last":true,"title":["A Phase I/II Clinical Trial of Preoperative Short-Course Carbon-Ion Radiotherapy for Patients With Squamous Cell Carcinoma of the Esophagus"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:52:38.794891+00:00"}