{"created":"2023-05-15T14:36:00.375929+00:00","id":46340,"links":{},"metadata":{"_buckets":{"deposit":"9ae20926-27c4-47c6-b7da-12b93eb87276"},"_deposit":{"created_by":1,"id":"46340","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"46340"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00046340","sets":["1"]},"author_link":["461655","461658","461656","461657","461659","461653","461654","461660"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"10","bibliographicPageEnd":"795","bibliographicPageStart":"787","bibliographicVolumeNumber":"25","bibliographic_titles":[{"bibliographic_title":"Annals of Nuclear Medicine"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objective This study was a controlled multicenter clinical\nstudy on patients with peripheral lung nodules to verify the\nimprovement in the diagnostic ability of FDG-PET when\nused in combination with thin-section CT (TS-CT).\nMethods Patients with peripheral lung nodules (long\nmaximal diameter: 10–30 mm) detected using CT were\nexamined using TS-CT and FDG-PET for the differential\ndiagnosis of benign or malignant lesions. The primary\nendpoint was the specificity of the results using a combination\nof TS-CT and FDG-PET, compared with the results\nfor TS-CT alone. Images were interpreted by investigators\nat each institution. Blind readings were also performed by\nan independent image interpretation committee. The gold\nstandard was a pathological diagnosis determined using a\nsurgical or biopsy specimen obtained after PET; and the\npatients in whom a pathological diagnosis could not be\nobtained were diagnosed based on a follow-up TS-CT\nperformed more than 6 months later. Adverse reactions to\nFDG were also evaluated.\nResults The blind reading results for 82 lesions in 81\nsubjects eligible for analysis among the 90 subjects included\nin the study showed a specificity of 91.2% (31/34)\n(95% CI: 76.3–98.1) for TS-CT ? PET, compared with a\nspecificity of 67.6% (23/34) (95% CI: 49.5–82.6) for TSCT\nalone. The specificity was significantly improved by the\naddition of the PET findings (p.05). The sensitivity\nimproved from 89.6% (43/48) for TS-CT to 91.7% (44/48)\nfor TS-CT ? PET; the addition of PET increased the level\nof confidence in the diagnosis, but the difference was not\nsignificant. The results reported by the institutional investigators\nwere not significantly different. No serious adverse\nreactions occurred, although two of the 90 subjects\nexhibited mild adverse reactions.\nConclusions The addition of FDG-PET to TS-CT for the\ndifferential diagnosis of benign or malignant peripheral\nlung nodules resulted in a significant improvement in\nspecificity. Although a definitive diagnosis of lung nodules\nrequires a histopathological or cytological examination,\nwhen combined with TS-CT, FDG-PET can provide\nadditional diagnostic information and improve the\nspecificity.","subitem_description_type":"Abstract"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1007/s12149-011-0528-5","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0914-7187","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kubota, Kazuo"}],"nameIdentifiers":[{"nameIdentifier":"461653","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Murakami, Koji"}],"nameIdentifiers":[{"nameIdentifier":"461654","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Inoue, Tomio"}],"nameIdentifiers":[{"nameIdentifier":"461655","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Saga, Tsuneo"}],"nameIdentifiers":[{"nameIdentifier":"461656","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shiomi, Susumu"}],"nameIdentifiers":[{"nameIdentifier":"461657","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"村上 康二","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"461658","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"井上 登美夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"461659","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐賀 恒夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"461660","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Additional effects of FDG-PET to thin-section CT for the differential diagnosis of lung nodules: a Japanese multicenter clinical study","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Additional effects of FDG-PET to thin-section CT for the differential diagnosis of lung nodules: a Japanese multicenter clinical study"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-06-06"},"publish_date":"2012-06-06","publish_status":"0","recid":"46340","relation_version_is_last":true,"title":["Additional effects of FDG-PET to thin-section CT for the differential diagnosis of lung nodules: a Japanese multicenter clinical study"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:53:00.224146+00:00"}