@article{oai:repo.qst.go.jp:00046334, author = {Hasegawa, Azusa and Mizoe, Junetsu and Tsujii, Hirohiko and Kamada, Tadashi and Jingu, Keiichi and Iwadate, Yasuo and Nakazato, Youichi and Matsutani, Masao and Takakura, Kintomo and 長谷川 安都佐 and 溝江 純悦 and 辻井 博彦 and 鎌田 正 and 神宮 啓一 and 岩立 康男 and 中里 洋一 and 松谷 雅生 and 高倉 公朋}, issue = {1}, journal = {International Journal of Radiation Oncology Biology Physics}, month = {Jun}, note = {Between October 1994 and February 2002, 14 patients with diffuse astrocytoma were enrolled in a phase I/II clinical trial of carbon ion radiotherapy. Carbon ion radiotherapy was administered in 24 fractions over 6 weeks. The carbon ion dose was escalated from 50.4 Gy equivalent (GyE) to 55.2 GyE. Patients were divided into two groups according to their carbon ion doses: a low-dose group in 9 patients and a high-dose group in 5 patients. High-dose group showed significant improvement in PFS and OS rates compared to those in the low-dose group. Toxicities were within acceptable limits. None of the patients developed a Grade 1 or higher acute brain reaction (RTOG), and a Grade 3 or higher late brain reaction (RTOG/ EORTC).}, pages = {100--106}, title = {Experience with Carbon Ion Radiotherapy for WHO Grade 2 Diffuse Astrocytomas}, volume = {83}, year = {2011} }