@article{oai:repo.qst.go.jp:00046330,
 author = {Fujita, Kazuko and Akasaka, Yoshikiyo and Kuwabara, Taku and Bing, Wang and Tanaka, Kaoru and Ishii, Toshiharu and et.al and 藤田 和子 and 桑原 卓 and 王 冰 and 田中 薫},
 issue = {1/2},
 journal = {Immunology Letters},
 month = {Feb},
 note = {Toll-like receptors appear to play an important role in the pathogenesis of lupus-like nephritis in mice. In human and mouse, CD180 is a homologue of TLR4. In SLE patients, the number of CD180-negative B cells in peripheral blood changes in parallel with disease activity. In the present study using NZBWF1 mice, the population of splenic CD180-negative B cells increased with progression of renal lesions and aging. These cells produced both anti-dsDNA and histone antibodies; the peripheral blood levels of anti-dsDNA antibody increased markedly with aging. B cells infiltrating into renal lesions were CD180-negative and produced anti-dsDNA antibody. Considered together, these findings indicate that CD180-negative B cells contribute significantly to development of SLE-like morbidity in NZBWF1 mice by autoantibody production.},
 pages = {1--6},
 title = {Pathogenesis of lupus-like nephritis through autoimmune antibody produced by CD180-negative B lymphocytes in NZBWF1 mouse},
 volume = {144},
 year = {2012}
}