@article{oai:repo.qst.go.jp:00046329,
 author = {Hayashi, Kazutaka and Furutsuka, Kenji and Ito, Takehito and Mutou, Masatoshi and Aki, Hatsumi and Fukumura, Toshimitsu and Suzuki, Kazutoshi and 古塚 賢士 and 福村 利光 and 鈴木 和年},
 issue = {3},
 journal = {Journal of Labelled Compounds & Radiopharmaceuticals},
 month = {Jan},
 note = {We have developed an efficient synthesis method for the rapid and high-yield automated synthesis of 4-(2'-methoxyphenyl)-
1-[2'-(N-2"-pyridinyl)-p-[18F]fluorobenzamido]ethylpiperazine (p-[18F]MPPF). No-carrier-added [18F]F1 was trapped on a small
QMA cartridge and eluted with 70% MeCN(aq) (0.4 mL) containing Kryptofix 222 (2.3 mg) and K2CO3 (0.7 mg). The nucleophilic
[18F]fluorination was performed with 3mg of the nitro-precursor in DMSO (0.4 mL) at 190 C for 20 min, followed by the
preparative HPLC purification (column: COSMOSIL Cholester, Nacalai Tesque, Kyoto, Japan; mobile phase: MeCN/25mM
AcONH4/AcOH = 200/300/0.15; flow rate: 6.0 mL/min) to afford p-[18F]MPPF (retention time = 9.5 min). p-[18F]MPPF was
obtained automatically with a radiochemical yield of 38.6 5.0% (decay corrected, n = 5), a specific activity of 214.3 21.1
GBq/mmol, and a radiochemical purity of >99% within a total synthesis time of about 55 min.},
 pages = {120--124},
 title = {Fully automated synthesis and purification of 4-(2'-methoxyphenyl)-1-[2'-(N-2''-pyridinyl)- p-[18F]fluorobenzamido]ethylpiperazine},
 volume = {55},
 year = {2012}
}