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Fully automated synthesis and purification of 4-(2'-methoxyphenyl)-1-[2'-(N-2''-pyridinyl)- p-[18F]fluorobenzamido]ethylpiperazine
https://repo.qst.go.jp/records/46329
https://repo.qst.go.jp/records/46329b65bb6bd-c8e4-44ab-b01e-7719e5c021b4
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2012-05-30 | |||||
| タイトル | ||||||
| タイトル | Fully automated synthesis and purification of 4-(2'-methoxyphenyl)-1-[2'-(N-2''-pyridinyl)- p-[18F]fluorobenzamido]ethylpiperazine | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Hayashi, Kazutaka
× Hayashi, Kazutaka× Furutsuka, Kenji× Ito, Takehito× Mutou, Masatoshi× Aki, Hatsumi× Fukumura, Toshimitsu× Suzuki, Kazutoshi× 古塚 賢士× 福村 利光× 鈴木 和年 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We have developed an efficient synthesis method for the rapid and high-yield automated synthesis of 4-(2'-methoxyphenyl)- 1-[2'-(N-2"-pyridinyl)-p-[18F]fluorobenzamido]ethylpiperazine (p-[18F]MPPF). No-carrier-added [18F]F1 was trapped on a small QMA cartridge and eluted with 70% MeCN(aq) (0.4 mL) containing Kryptofix 222 (2.3 mg) and K2CO3 (0.7 mg). The nucleophilic [18F]fluorination was performed with 3mg of the nitro-precursor in DMSO (0.4 mL) at 190 C for 20 min, followed by the preparative HPLC purification (column: COSMOSIL Cholester, Nacalai Tesque, Kyoto, Japan; mobile phase: MeCN/25mM AcONH4/AcOH = 200/300/0.15; flow rate: 6.0 mL/min) to afford p-[18F]MPPF (retention time = 9.5 min). p-[18F]MPPF was obtained automatically with a radiochemical yield of 38.6 5.0% (decay corrected, n = 5), a specific activity of 214.3 21.1 GBq/mmol, and a radiochemical purity of >99% within a total synthesis time of about 55 min. |
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| 書誌情報 |
Journal of Labelled Compounds & Radiopharmaceuticals 巻 55, 号 3, p. 120-124, 発行日 2012-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0362-4803 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1002/jlcr.1958 | |||||
