{"created":"2023-05-15T14:35:57.569454+00:00","id":46275,"links":{},"metadata":{"_buckets":{"deposit":"3d9d8ead-2bc1-4c45-b989-f7d07cef3c6f"},"_deposit":{"created_by":1,"id":"46275","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"46275"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00046275","sets":["1"]},"author_link":["460928","460930","460927","460941","460932","460945","460946","460940","460934","460926","460922","460923","460936","460931","460924","460942","460949","460947","460937","460933","460935","460948","460943","460925","460939","460929","460944","460938"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"99","bibliographicPageStart":"89","bibliographicVolumeNumber":"39","bibliographic_titles":[{"bibliographic_title":"Nuclear Medicine and Biology"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Introduction: To explore the possible use of positron emission tomography (PET) probes for imaging of I2-imidazoline receptors (I2Rs) in peripheral tissues, we labeled two new I2R ligands, 2-[2-(o-tolyl)vinyl]-4,5-dihydro-1H-imidazole (Ki for I2Rs, 3.7 nM) and 2-[2-(o-tolyl) ethyl]-4,5-dihydro-1H-imidazole (Ki for I2Rs, 1.7 nM) with 11C ([11C]metrazoline and [11C]TEIMD), respectively, and evaluated these\nligands and the recently developed I2R ligand 2-[3-fluoro-[4-11C]tolyl]-4,5-dihydro-1H-imidazole ([11C]FTIMD) by in vivo studies.\nMethods: [11C]Metrazoline and [11C]TEIMD were prepared by a palladium-promoted cross-coupling reaction of the tributylstannyl precursor and [11C]methyl iodide. Their biodistribution in mice was investigated by tissue dissection. In addition, PET scans and metabolite analysis were performed.\nResults: [11C]Metrazoline and [11C]TEIMD were successfully synthesized with a suitable radioactivity for injection. In the liver and pancreas expressing I2Rs, coinjection with the high-affinity I2R ligand, BU224, induced a reduction in the radioactivity level at 30 min after \ninjection of [11C]metrazoline and [11C]FTIMD. However, the radioactivity level after injection of [11C]TEIMD was unchanged. In the PET\nstudy, coinjection with BU224 induced a decrease in the radioactivity level in the liver and pancreas after more than 15 min of injection of\n[11C]metrazoline and [11C]FTIMD as compared with the results obtained for controls. In metabolite analysis, coinjection with BU224 induced a significant reduction in the percentage of unchanged [11C]metrazoline at 30 min after injection as compared with that in the control, although no significant difference was observed in the percentage of unchanged [11C]FTIMD.\nConclusion: [11C]Metrazoline may be a more useful PET probe than [11C]FTIMD for imaging of I2Rs in peripheral tissues.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0969-8051","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kawamura, Kazunori"}],"nameIdentifiers":[{"nameIdentifier":"460922","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yui, Joji"}],"nameIdentifiers":[{"nameIdentifier":"460923","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Konno, Fujiko"}],"nameIdentifiers":[{"nameIdentifier":"460924","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamasaki, Tomoteru"}],"nameIdentifiers":[{"nameIdentifier":"460925","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hatori, Akiko"}],"nameIdentifiers":[{"nameIdentifier":"460926","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Wakizaka, Hidekatsu"}],"nameIdentifiers":[{"nameIdentifier":"460927","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fujinaga, Masayuki"}],"nameIdentifiers":[{"nameIdentifier":"460928","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kumata, Katsushi"}],"nameIdentifiers":[{"nameIdentifier":"460929","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshida, Yuichirou"}],"nameIdentifiers":[{"nameIdentifier":"460930","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ogawa, Masanao"}],"nameIdentifiers":[{"nameIdentifier":"460931","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nengaki, Nobuki"}],"nameIdentifiers":[{"nameIdentifier":"460932","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yanamoto, Kazuhiko"}],"nameIdentifiers":[{"nameIdentifier":"460933","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fukumura, Toshimitsu"}],"nameIdentifiers":[{"nameIdentifier":"460934","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Ming-Rong"}],"nameIdentifiers":[{"nameIdentifier":"460935","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"河村 和紀","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"460936","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"由井 譲二","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"460937","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"昆野 富士子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"460938","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山崎 友照","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"460939","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"羽鳥 晶子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"460940","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"脇坂 秀克","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"460941","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤永 雅之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"460942","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"熊田 勝志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"460943","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉田 勇一郎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"460944","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小川 政直","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"460945","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"念垣 信樹","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"460946","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"柳本 和彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"460947","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"福村 利光","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"460948","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 明栄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"460949","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Synthesis and evaluation of PET probes for the imaging of I2 imidazoline receptors in peripheral tissues","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Synthesis and evaluation of PET probes for the imaging of I2 imidazoline receptors in peripheral tissues"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-02-24"},"publish_date":"2012-02-24","publish_status":"0","recid":"46275","relation_version_is_last":true,"title":["Synthesis and evaluation of PET probes for the imaging of I2 imidazoline receptors in peripheral tissues"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:53:48.157227+00:00"}