{"created":"2023-05-15T14:35:55.886555+00:00","id":46236,"links":{},"metadata":{"_buckets":{"deposit":"f686d9f9-9772-4d19-a901-0dbf3726e677"},"_deposit":{"created_by":1,"id":"46236","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"46236"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00046236","sets":["1"]},"author_link":["929657","929655","929658","929656","929662","929654","929661","929659","929660"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"219","bibliographicPageStart":"212","bibliographicVolumeNumber":"492","bibliographic_titles":[{"bibliographic_title":"Gene"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Hemoglobin of bony fish and higher vertebrates is a tetrameric protein\nconstructed by 2 a- and 2 b-globins, which are expressed in a developmental\nstage-specific manner. The genomic organization of genes for embryonic and\nadult a- and b-globin varies from species to species. In fish, it is known that there\nis a unique genomic organization of globin genes, that is, a- and b-globin genes\nare arranged in a bi-directional and head-to-head orientation with respect to\ntranscription start sites. In medaka, we have demonstrated that 14 globin genes\nare located in 2 different clusters, and 5 pairs of the a- and b-globin genes were\nfound to be organized in a head-to-head orientation. The developmental\nexpression patterns of the 11 globin genes were classified into 4 types. To clarify\nhow their developmental stage-specific expressions are regulated, we produced\n4 types of GFP- or RFP-transgenic medaka. Such transgenic medaka revealed\nthat each of the 1-1.7 kbp 5 upstream sequences from respective globin genes\npossesses the ability to regulate the developmental stage-specific globin gene\nexpression. In particular, the intervals between head-to-head a3 and b3, and a4\nand b4 genes controlled the synchronized expression of the globin genes\nlocated at both sides of the intervals, which is significant to understand the\nmechanism by which equal amounts of a- and b-globins are expressed in\nerythroid cells. We also demonstrated that the head-to-head intervals can\ncontrol the expression of the globin genes located at both sides. These findings\nare significant to understand the mechanism by which a- and b-globins are\nequally expressed in erythroid cells.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0378-1119","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Maruyama, Kouichi"}],"nameIdentifiers":[{"nameIdentifier":"929654","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Bing, Wang"}],"nameIdentifiers":[{"nameIdentifier":"929655","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishikawa, Yuji"}],"nameIdentifiers":[{"nameIdentifier":"929656","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yasumasu, Shigeki"}],"nameIdentifiers":[{"nameIdentifier":"929657","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Iuchi, Ichiro"}],"nameIdentifiers":[{"nameIdentifier":"929658","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kouichi, Maruyama","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"929659","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Bing, Wang","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"929660","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yuuji, Ishikawa","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"929661","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shigeki, Yasumasu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"929662","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"1 kbp 5' upstream sequence enables developmental stage-specific expressions of globin genes in the fish, medaka Oryzias latipes.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"1 kbp 5' upstream sequence enables developmental stage-specific expressions of globin genes in the fish, medaka Oryzias latipes."}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-10-11"},"publish_date":"2011-10-11","publish_status":"0","recid":"46236","relation_version_is_last":true,"title":["1 kbp 5' upstream sequence enables developmental stage-specific expressions of globin genes in the fish, medaka Oryzias latipes."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:40:42.735972+00:00"}