{"created":"2023-05-15T14:35:54.896191+00:00","id":46213,"links":{},"metadata":{"_buckets":{"deposit":"75352bc7-3cbc-483e-8996-bf555ca2181e"},"_deposit":{"created_by":1,"id":"46213","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"46213"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00046213","sets":["1"]},"author_link":["460174","460175","460180","460173","460176","460178","460172","460177","460179"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"11","bibliographicPageEnd":"801","bibliographicPageStart":"790","bibliographicVolumeNumber":"28","bibliographic_titles":[{"bibliographic_title":"Zoological Science"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"In our laboratory, a single autosomal recessive mutation in a phenotype similar to ruby-eye (ru/\nHps6ru) or ruby-eye 2 (ru2/Hps5ru2) spontaneously occurred in siblings of C57BL/10JHir (+/+, black)\nmice in 2006. RT-PCR analysis revealed that this novel mutation, named ru2d/Hps5ru2-d, exhibited\nframeshift by 997G deletion in the Hps5 gene. To clarify the mechanism of the hypopigmentation,\nthe characteristics of proliferation and differentiation of ru2d/ru2d epidermal melanoblasts and melanocytes\ncultured in a serum-free medium were investigated. The proliferation of ru2d/ru2d melanoblasts\nand melanocytes did not differ from that of +/+ melanoblasts and melanocytes. However, the\ndifferentiation of ru2d/ru2d melanocytes was greatly inhibited. Tyrosinase (TYR) activity, expression\nof TYR, TYR-related protein 1 (TRP1) and TRP2 (dopachrome tautomerase, DCT), eumelanin synthesis,\nand the number of stage IV melanosomes markedly decreased in ru2d/ru2d melanocytes.\nHowever, excess L-tyrosine (Tyr) added to culture media from initiation of the primary culture rescued\nthe reduced differentiation through increase in TYR activity, expression of TYR, TRP1, TRP2\nand Kit, eumelanin synthesis, and stage IV melanosomes. L-Tyr injected into ru2d/ru2d mice also\nstimulated melanocyte differentiation. These results suggest that the ru2d allele inhibits melanocyte\ndifferentiation, and that its impaired differentiation is rescued by excess Tyr.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0289-0003","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hirobe, Tomohisa"}],"nameIdentifiers":[{"nameIdentifier":"460172","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshihara, Chihiro"}],"nameIdentifiers":[{"nameIdentifier":"460173","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takeuchi, Sakae"}],"nameIdentifiers":[{"nameIdentifier":"460174","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Wakamatsu, Kazumasa"}],"nameIdentifiers":[{"nameIdentifier":"460175","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ito, Shosuke"}],"nameIdentifiers":[{"nameIdentifier":"460176","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Abe, Hiroyuki"}],"nameIdentifiers":[{"nameIdentifier":"460177","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kawa, Yoko"}],"nameIdentifiers":[{"nameIdentifier":"460178","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Soma, Yoshinao"}],"nameIdentifiers":[{"nameIdentifier":"460179","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"廣部 知久","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"460180","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"A Novel Deletion Mutation of Mouse Ruby-eye 2 Named ru2d/Hps5ru2-d Inhibits Melanocyte Differentiation and Its Impaired Differentiation is Rescued by L-tyrosine","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A Novel Deletion Mutation of Mouse Ruby-eye 2 Named ru2d/Hps5ru2-d Inhibits Melanocyte Differentiation and Its Impaired Differentiation is Rescued by L-tyrosine"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-11-22"},"publish_date":"2011-11-22","publish_status":"0","recid":"46213","relation_version_is_last":true,"title":["A Novel Deletion Mutation of Mouse Ruby-eye 2 Named ru2d/Hps5ru2-d Inhibits Melanocyte Differentiation and Its Impaired Differentiation is Rescued by L-tyrosine"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:54:31.752059+00:00"}