{"created":"2023-05-15T14:35:54.205352+00:00","id":46197,"links":{},"metadata":{"_buckets":{"deposit":"9880451e-2a60-4bb9-b367-a6fd222bd53f"},"_deposit":{"created_by":1,"id":"46197","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"46197"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00046197","sets":["1"]},"author_link":["460024","460023","460012","460025","460026","460027","460029","460010","460011","460021","460013","460018","460015","460022","460016","460017","460028","460019","460014","460020"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"10","bibliographicPageEnd":"e25487","bibliographicPageStart":"e25487","bibliographicVolumeNumber":"6","bibliographic_titles":[{"bibliographic_title":"PLoS ONE (Online only:URL:http://www.plosone.org)"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Transplantation of mononuclear cells (MNCs) has previously been tested as a method to induce therapeutic angiogenesis to treat limb ischemia in clinical trials. Non-invasive high resolution imaging is required to track the cells and\nevaluate clinical relevance after cell transplantation. The hypothesis that MRI can provide in vivo detection and long-term observation of MNCs labeled with manganese contrast-agent was investigated in ischemic rat legs.\nMethods and Findings: The Mn-labeled MNCs were evaluated using 7-tesla high-field magnetic resonance imaging (MRI). Intramuscular transplanted Mn-labeled MNCs were visualized with MRI for at least 7 and up to 21 days after transplantation in the ischemic leg. The distribution of Mn-labeled MNCs was similar to that of 111In-labeled MNCs measured with singlephoton emission computed tomography (SPECT) and DiI-dyed MNCs with fluorescence microscopy. In addition, at 1–2 days after transplantation the volume of the site injected with intact Mn-labeled MNCs was significantly larger than that injected with dead MNCs, although the dead Mn-labeled MNCs were also found for approximately 2 weeks in the ischemic legs. The\narea covered by CD31-positive cells (as a marker of capillary endothelial cells) in the intact Mn-MNCs implanted site at 43 days was significantly larger than that at a site implanted with dead Mn-MNCs.\nConclusions: The present Mn-enhanced MRI method enabled visualization of the transplanted area with a 150–175 mm inplane spatial resolution and allowed the migration of labeled-MNCs to be observed for long periods in the same subject.\nAfter further optimization, MRI-based Mn-enhanced cell-tracking could be a useful technique for evaluation of cell therapy both in research and clinical applications.","subitem_description_type":"Abstract"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1371/journal.pone.0025487","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1932-6203","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Odaka, Kenichi"}],"nameIdentifiers":[{"nameIdentifier":"460010","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Aoki, Ichio"}],"nameIdentifiers":[{"nameIdentifier":"460011","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Moriya, Junji"}],"nameIdentifiers":[{"nameIdentifier":"460012","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tateno, Kaoru"}],"nameIdentifiers":[{"nameIdentifier":"460013","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tadokoro, Hiroyuki"}],"nameIdentifiers":[{"nameIdentifier":"460014","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kershaw, Jeffrey"}],"nameIdentifiers":[{"nameIdentifier":"460015","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Minamino, Tohru"}],"nameIdentifiers":[{"nameIdentifier":"460016","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Irie, Toshiaki"}],"nameIdentifiers":[{"nameIdentifier":"460017","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fukumura, Toshimitsu"}],"nameIdentifiers":[{"nameIdentifier":"460018","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Komuro, Issei"}],"nameIdentifiers":[{"nameIdentifier":"460019","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Saga, Tsuneo"}],"nameIdentifiers":[{"nameIdentifier":"460020","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小高 謙一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"460021","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"青木 伊知男","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"460022","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"森谷 純治","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"460023","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"舘野 馨","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"460024","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田所 裕之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"460025","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ｋｅｒｓｈａｗ Ｊｅｆｆｒｅｙ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"460026","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"入江 俊章","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"460027","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"福村 利光","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"460028","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐賀 恒夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"460029","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"In vivo tracking of transplanted mononuclear cells using manganese-enhanced magnetic resonance imaging (MEMRI)","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"In vivo tracking of transplanted mononuclear cells using manganese-enhanced magnetic resonance imaging (MEMRI)"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-11-08"},"publish_date":"2011-11-08","publish_status":"0","recid":"46197","relation_version_is_last":true,"title":["In vivo tracking of transplanted mononuclear cells using manganese-enhanced magnetic resonance imaging (MEMRI)"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:54:42.867719+00:00"}